摘要
目的:比较不同锌制剂治疗及预防小儿抗生素相关性腹泻的临床效果。方法:纳入本院2019年1月—2020年 2月诊治的150例抗生素相关性腹泻患儿为研究对象,按摸球法分为两组,均在原发病治疗基础上予以微生态制剂、调整饮食、保护胃肠道黏膜等常规治疗,对照组(n=75)应用葡萄糖酸锌治疗,观察组(n=75)应用锌硒制剂治疗,两组均治疗10 d。比较两组患儿治疗后总体疗效、临床症状缓解时间差异,并随访3个月,比较两组腹泻情况。结果:观察组小儿抗生素相关性腹泻总体有效率与对照组相比,差异无统计学意义(P>0.05);观察组平均临床症状缓解时间(3.21±0.65)d,短于对照组的(4.97±1.34)d(P<0.05);观察组停药后3个月的腹泻复发率为1.33%,低于对照组的10.67%(P<0.05)。结论:锌制剂治疗小儿抗生素相关性腹泻的临床效果显著,而锌硒制剂在加速康复、预防腹泻方面效果更佳,建议推广。
Objective:To compare the clinical effects of different zinc preparations in the treatment and prevention of antibiotic associated diarrhea in children.Methods:150 cases of antibiotic associated diarrhea in our hospital from January 2019 to February 2020 were selected as the research objects.They were divided into two groups according to the method of touching the ball.On the basis of the treatment of the primary disease,they were given routine treatment such as microecological preparation,diet adjustment and protection of gastrointestinal mucosa.The control group(n=75)was treated with zinc gluconate,and the observation group(n=75)was treated with zinc selenium preparation.The overall efficacy and clinical symptom relief time of the two groups were compared,and the diarrhea situation of the two groups was compared after 3 months of follow-up.Results:There was no significant difference in the overall effective rate of antibiotic associated diarrhea between the observation group and the control group(P>0.05);the average remission time of clinical symptoms in the observation group was(3.21±0.65)d,which was shorter than(4.97±1.34)d in the control group(P<0.05);the incidence of diarrhea in the observation group 3 months after drug withdrawal was 1.33%,which was lower than 10.67%of the control group(P<0.05).Conclusion:Zinc preparation has significant clinical effect in the treatment of antibiotic associated diarrhea in children,and zinc selenium preparation has better effect in accelerating rehabilitation and preventing diarrhea,so it is recommended to be popularized.
作者
邓菲妮
DENG Feini(Department of Pediatrics,the Second People's Hospital of Loudi,Loudi Hunan 417000,China)
出处
《药品评价》
CAS
2020年第14期15-16,19,共3页
Drug Evaluation
关键词
锌硒制剂
葡萄糖酸锌
小儿抗生素相关性腹泻
Zinc Selenium Preparation
Zinc Gluconate
Antibiotic Related Diarrhea in Children
