摘要
目的探讨长链非编码RNA-SChLAP1过表达对结直肠癌(CRC)预后的影响。方法选取符合严格随访标准的156例CRC患者和43例癌旁结直肠组织进行qRT-PCR检测,评估SChLAP1表达与CRC临床病理特征和总生存期(OS)、无病生存期(DFS)的关系,以及影响CRC患者OS和DFS的风险因素。结果CRC中SChLAP1水平明显高于癌旁结直肠组织,差异有统计学意义(P<0.01)。SChLAP1高表达与CRC的分化和分期有关,也与DFS和OS有关(P<0.01)。Cox比例风险回归模型发现SChLAP1表达是CRC患者OS和DFS下降的独立风险因素。结论SChLAP1在CRC进展中起着重要作用,SChLAP1可能作为独立的生物标志物用于CRC的预后评估。
Objective To investigate the effect of long-chain non-coding RNA-SChLAP1 overexpression on the prognosis of colorectal cancer(CRC).Methods A total of 156 CRC patients and 43 adjacent colorectal tissue of CRC were selected for qRT-PCR.The correlation between SChLAP1 expression and the clinicopathological characteristics,overall survival(OS),disease-free survival(DFS),and risk factors for OS and DFS in CRC patients were evaluated.Results The level of SChLAP1 in CRC was significantly higher than that in adjacent colorectal tissues,and the differences were statistically significant(P<0.01).The high expression of SChLAP1 was related to the differentiation and stage of CRC,DFS and OS(P<0.01).SChLAP1 expression was an independent risk factor for the OS and DFS of CRC patients.Conclusion SChLAP1 plays an important role in the progression of CRC.SChLAP1 may be used as an independent biomarker for the prognosis of CRC.
作者
孙小艳
张晓艳
SUN Xiaoyan;ZHANG Xiaoyan(Department of Gastroenterology,Dandong First Hospital,Dandong 118001,China;Department of Pathology,Fifth People′s Hospital of Shenyang City & Shenyang Tumor Hospital)
出处
《实用肿瘤学杂志》
CAS
2020年第5期425-429,共5页
Practical Oncology Journal
