摘要
目的:为进一步开发与应用儿童生存质量测量量表(PedsQL)提供参考。方法:以“PedsQL”为检索词系统检索Medline、ScienceDirect、Cochrane图书馆、ISI Web of Science、SpringerLink、Embase、中国知网、万方数据、维普网、中国生物医学文献服务系统等中英文数据库,对发表日期为1999年1月-2019年12月的有关PedsQL在国内外的应用研究文献进行检索。结果与结论:共纳入文献2117篇,其中国外文献1836篇、国内文献281篇(中文242篇、英文39篇);文献发表数量基本呈现逐年增长的趋势。PedsQL量表在国内外应用广泛,依据用途可划分为4个主要领域,分别为健康影响因素分析(63项研究)、疾病负担评估(1720项研究)、干预措施效果评价(285项研究)、其他量表的理论研究(49项研究)。PedsQL量表应用于临床研究进展迅速,但我国研究仍存在量表的选择与使用方法不当、在儿科临床实践领域应用偏少、对干预措施评价不够全面的问题。建议学者未来在选用工具时同时考虑普适性与疾病特异性、自填与家长代理版本PedsQL量表,应用PedsQL量表实施常规的临床健康相关生存质量筛查以优化儿科卫生资源使用效率,构建基于我国人群偏好的PedsQL量表映射函数以进行药物干预措施的经济学评价。
OBJECTIVE:To provide reference for the development and application of the pediatric quality of life inventory(PedsQL).METHODS:Using“PedsQL”as keyword,retrieved from foreign databases as Medline,ScienceDirect,Cochrane Library,ISI Web of Science,SpringerLink and Embase,Chinese databases as CNKI,Wanfang database,VIP and SinoMed,research literatures about the application of PedsQL at home and abroad were collected during Jan.1999-Dec.2019.RESULTS&CONCLUSIONS:A total of 2117 literatures were included,including 1836 foreign literatures and 281 domestic literatures(242 in Chinese,39 in English).The number of published literatures was increasing year by year.PedsQL had a wide range of applications and divided into 4 main areas according to purpose,including analysis of health influencing factors(63 items),assessment of diseases burden(1720 items),evaluation of intervention measures(285 items),theoretical study of other scales(49 items).The application of PedsQL in clinical trials had made fast progress,but there were still some problems in China,such as improper selection and use of the scale,less application in pediatric clinical practice,and insufficient evaluation of intervention measures.It is suggested that future researcher should consider both universality and disease specificity,self-administered and parental surrogate version of PedsQL when selecting tools,and apply PedsQL to perform routine clinical health-related quality of life screening to optimize the utilization efficiency of pediatric health resources,and construct PedsQL mapping function based on Chinese population preference to realize the economic evaluation of drug intervention measures.
作者
陈亮江
沃田
陈磊
席晓宇
CHEN Liangjiang;WO Tian;CHEN Lei;XI Xiaoyu(Research Center of National Drug Policy&Ecosystem,China Pharmaceutical University,Nanjing 211198,China)
出处
《中国药房》
CAS
北大核心
2020年第20期2539-2545,共7页
China Pharmacy
基金
国家科技重大专项“重大新药创制”专项项目(No.2018ZX09721-003)
国家卫生健康委员会卫生技术评估重点实验室(复旦大学)开放基金课题(No.FHTA2019-06)
中国药科大学“双一流”学科创新团队建设项目(No.CPU2018GY39)。
