摘要
目的 :探讨联用纳络酮及大剂量维生素C治疗新生儿缺氧缺血性脑病 (HIE)的临床疗效。方法 :将 38例HIE患儿分为 2组 ,观察组 2 0例在常规治疗的基础上采用纳络酮 0 .0 2～ 0 .0 4mg .kg-1.d-1及大剂量维生素C(1.0g .kg-1.d-1)静滴治疗 ;常规组 18例仅用常规方法治疗。结果 :观察组临床疗效显效率为 6 5 .0 0 %,总有效率为 85 .0 0 %,常规组分别为 2 7.78%及 6 1.11%,2组比较差异均有显著性 (P均 <0 .0 1)。观察组临床症状、体征全部消失时间 (5 .2 0± 2 .6 8)日较常规组 (9.36± 3.82 )日明显缩短 (P <0 .0 1)。结论 :联用纳络酮及大剂量维生素C治疗新生儿缺氧缺血性脑病疗效明显优于常规治疗。
Objective: To evaluate the clinically curative effects of combination of naloxone and large dosages of vitamin C injection on neonates with hypoxia ischemic encephalopathy(HIE). Methods: 38 sick neonates with HIE were divided into two groups at random. The observation group(n=20) based on conventional therapy was treated with naloxone(0.02～0.04mg.kg/d) injected and large dosages of vitamin C (1.0g.kg/d) infused intravenusly, otherwise convention group (n=18) treated with conventional therapy alone. Results: The markedly effectiverate was 65.00% and total effective rate was 85.00% in observation group but they were 27.78% and 61.11% respectively in convention group. In comparison between two groups the differences were significant(both P<0.01). The mean time for all of the symptoms and signs to disappear(5.20±2.68) d in observation group was significantly shorter than that (9.36±3.82) d in convention group (P<0.01). Conclusion: The curative effects treated with combination of naloxon and large dosages of vitamin C injection on neonates with HIE are significantly superior to those treated with conventional therapy.
出处
《河北医学》
CAS
2002年第9期782-784,共3页
Hebei Medicine
