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幽门螺杆菌感染与胃液中一氧化氮的关系 被引量:1

Correlation Between Helicobacter Pylori and Nitric Oxide in the Gastric Juice
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摘要 目的 :探讨胃液中一氧化氮浓度与Hp感染和非感染的关系。方法 :应用硝酸还原酶法 ,通过光度比色测定 36例患者胃液中一氧化氮的浓度。结果 :Hp阳性患者胃液中一氧化氮浓度平均为92 .3+/ - 15 .2 μmol/L ;Hp阴性患者为 132 .2 +/ - 16 .7μmol/L ,明显高于阳性组 (P <0 .0 1)。结论 :Hp感染导致胃液中一氧化氮浓度降低 ,削弱了胃黏膜的防御功能。 Objective: To investigate the correlation between the concentration of Nitric Oxide (NO) in the gastric juice and helicobacter pylori(HP) infection. Method: The concentration of NO in the gastric juice was measured by the nitrate reductase through the color matching photometry in 36 cases. HP infection was tested with rapid urease test and historical examination and 13c urea breath test. Result: The concentration of NO in gastric juice was 92.3+/-15.2 umol/L in positive cases; it was significantly high with 132.2+/-umol/L in the HP negative cases. Conclusion: HP infection decrease the concentration of NO in the Gastric juice and damage the gastric defense ability.
出处 《河北医学》 CAS 2002年第9期774-775,共2页 Hebei Medicine
关键词 幽门螺杆菌感染 幽门螺杆菌 一氧化氮 胃液 硝酸还原酶法 Helicobacter pylori Nitrogen monoxide Gastric juice
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  • 1[1]Shiotani A,Yanaoka K,IguchM,et al. Helicobacter pylori infection reduces intraluminal nitric oxide in humans[J]. Gastroenterli,1999,34(6):668-74.
  • 2[2]Iguchi M, Shiotani A,Nishioka S,et al.Helicobacter pylori infection reduce intraluminal nitric oxide[J].Scand j Gastroenterol, 2000,35(7):694-8.
  • 3[3]Fandriks L, von Bothmer C, Aneman A, et al. Intragastric nitric oxide/nitrite in Helicobacter pylori-infected subjects[J]. Scand J Gastroenterol, 2001,36(4):347-50.
  • 4[4]A. Shiotani , M. Iguchi, I. Inoue, et al. Association between gastric myoelectrical activity and intraluminal nitric oxide. Alimentary Pharmacology & Therapeutics[J].Volume 16 Issue s2 Page 44 - April 2002.

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