摘要
妊娠合并肺癌十分少见,且临床表现不典型,发现时常为晚期,多预后不良。抗肿瘤治疗中,化疗为大多数患者首选治疗方法。本研究回顾性分析郑州大学第一附属医院收治的1例妊娠合并肺癌病例的临床资料,结合既往文献及71例病例,分析妊娠合并肺癌的临床特点。共有72例妊娠合并肺癌的病例被纳入本研究。72例病例中,中位确诊年龄为34岁;妊娠期确诊肺癌64例,中位确诊孕周31周(6~38周),妊娠中晚期确诊60例(93.75%);有明确吸烟史19例(26.39%);非小细胞肺癌59例(81.94%),小细胞肺癌13例(18.06%);临床分期为Ⅲ期及以上者65例(90.28%);有首诊症状的60例中咳嗽43例(71.67%),呼吸困难32例(53.33%),胸痛12例(20.00%),咯血10例(16.67%),体质量减轻13例(21.67%);分娩的中位孕周为33周(26~42周);在妊娠期接受治疗的患者共35例,3例早期治疗,23例化疗,7例行靶向治疗,5例行放射性治疗,1例手术。随访病例61例中,患者确诊肺癌后12个月的生存率为26.23%,胎儿随访无先天性畸形等报道。对于该病应重视孕前筛查及孕期不良反应,早期诊断,改善预后。
Lung cancer in pregnancy is very rare,and the clinical manifestations are not typical,often found to be advanced,more poor prognosis.In the anti-tumor treatment,chemotherapy is the preferred treatment for most patients.The clinical data of one case of pregnancy complicated with lung cancer admitted to the First Affiliated Hospital of Zhengzhou University were analyzed retrospectively.The clinical characteristics of pregnancy complicated with lung cancer were analyzed based on previous literature and 71 cases.A total of 72 pregnant women with lung cancer were included in this study.Among the 72 cases,the median age of diagnosis was 34 years old;64 cases of lung cancer were diagnosed during pregnancy,the median week was 31 weeks(6-38 weeks),60 cases(93.75%)were diagnosed in the second and third trimester of pregnancy;19 cases(26.39%)had a definite smoking history;59 cases(81.94%)were non-small cell lung cancer,13 cases(18.06%)were small cell lung cancer;65 cases(90.28%)were clinical stage III or above;Among 60 cases with first diagnosis symptoms,there were 43 cases(71.67%)of cough,32 cases(53.33%)of dyspnea,12 cases(20.00%)of chest pain,10 cases(16.67%)of hemoptysis,13 cases(21.67%)of body weight reduction;the median gestational week of delivery was 33 weeks(26-42 weeks);35 cases were treated in pregnancy,including 3 cases of early treatment,23 cases of chemotherapy,7 cases of targeted therapy,5 cases of radiation therapy,1 case of surgery.Among the 61 cases followed up,the 12-month survival rate was 26.23%after diagnosis of lung cancer.For this disease,we should pay attention to pre pregnancy screening and adverse reactions during pregnancy,early diagnosis,and improve the prognosis.
作者
袁文静
刘惠娜
马慧慧
赵先兰
YUAN Wen-jing;LIU Hui-na;MA Hui-hui;ZHAO Xian-lan(Department of Obstetrics,The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China;Department of Vasculocardiology,The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)
出处
《国际妇产科学杂志》
CAS
2020年第5期589-594,共6页
Journal of International Obstetrics and Gynecology
关键词
肺肿瘤
妊娠并发症
治疗
预后
病例报告
Lung neoplasms
Pregnancy complications
Therapy
Prognosis
Case reports
