摘要
1目的 探讨化疗栓塞术对肝癌病人肝脏血流动力学和肝储备功能 (HFR)的影响。2方法 对 17例肝癌病人行肝动脉插管化疗栓塞治疗 ,采用彩色多谱勒血流显像仪 (CDFI)显像、CT扫描测量的方法对栓塞前后的血流动力学和肝实质丢失率 (PHER)的改变进行临床观察。3结果 门静脉和脾静脉血流量、血流速度均于栓塞7d后明显上升 ,并达到高峰 (F=14.86～ 332 .5 5 ,q=6 .48～ 36 .43,P<0 .0 1) ,以后逐渐回落至栓塞前水平 ,而血管内径于栓塞前后无明显改变 ;门静脉充血指数 (CI)于栓塞前后无明显改变 (t=1.45 ,P>0 .0 5 ) ;栓塞后 PHER为10 .6 3%～ 43.83% ,平均 2 6 .13% ,多数病人 PHER<40 %时 ,栓塞后 HFR能满足术后代偿需要。4结论 对门静脉血流动力学的定量分析为肝动脉化疗栓塞术的预后估计提供了重要资料。综合 PHER可以正确评估栓塞对肝脏HFR的影响。
Objective\ To study the effects of hepatic arterial chemoembolization on hepatic hemodynamics and functional reserve (HFR) in patients with liver carcinoma.\ Methods\ Color doppler flow imaging (CDFI) and CT were used to make a comparision of hemodynamics and functional reserve changes before and after chemoembolization in 17 patients.\ Results\ The average PVF and SVF gradually reached their peaks at 1 week after embolization( F=14.86-332.55,q=6.48-36.43,P <0.01), then they gradually dropped to normal level, but the diameter of portal vein and splenic vein were not changed significantly. The congestion index (CI) of portal vein was not changed significantly ( t=1.45,P >0.05) before and after embolization. The parenchymal hepatic embolization ratio (PHER) was between 10.63%-43.83% (average 26.13%). If the PHER was below 40%, the HFR could be compensated for the need of liver function.\ Conclusion\ The quantitative analysis of portal venous hemodynamics can provide important index for the prognosis of HACE. The CI could help us analyze the change of portal vein pressure. According to PHER, we can calculate influence of HACE on HFR. [
出处
《青岛大学医学院学报》
CAS
2000年第3期187-189,共3页
Acta Academiae Medicinae Qingdao Universitatis
