摘要
目的:基于中医传承辅助平台挖掘中国知网数据库(CNKI)中以中医药治疗血栓闭塞性脉管炎的组方用药规律,为中医药治疗血栓闭塞性脉管炎提供临床参考。方法:检索CNKI数据库中近30年有关中医药治疗血栓闭塞性脉管炎的文献,筛选出符合条件的治疗血栓闭塞性脉管炎的中药方剂,利用中医传承辅助平台(V2.5)集成的数据分析方法,挖掘中医药治疗血栓闭塞性脉管炎的用药规律。结果:共筛选出410篇文献,符合条件处方600首,涉及233味中药。处方中药物出现频次≥60的药物得到33个,演化得到核心组合28个,新处方14个;药物主归肝、心、脾经,性味分别以温、寒、平和苦、辛、甘为主。结论:治疗血栓闭塞性脉管炎的药物立足于“血瘀”病机,以活血化瘀为主要治则,辅以清热、补虚、温通、息风止痉、止痛、托毒生肌、燥湿、通络等药物,在临床应用中灵活辨证施治。
Objective Based on the platform of traditional Chinese medicine inheritance,the prescription law of Chinese medicine for the treatment of thromboangiitis obliterans in CNKI database was mined to provide clinical reference for the treatment of thromboangiitis obliterans with traditional Chinese medicine.Methods Search the CNKI database for 30 years of literature on TCM for thromboocclusive vasculitis.Utilize the integrated data analysis method of traditional Chinese medicine inheritance auxiliary platform(V2.5)to discover the rules of traditional Chinese medicine for the treatment of thromboocclusive vasculitis.Results A total of 410 literatures were screened out through data mining,with 600 prescriptions meeting the conditions,which involving 233 Chinese medicines.There are 33 kinds of drugs that appear with the frequency of≥60 in the prescription and 28 core combinations were obtained by evolution and 14 new prescriptions were summarized finally.The drugs are directed to the liver,heart and spleen meridian.Their properties and tastes are mainly warm,cold,peaceful,bitter,pungent and sweet.Conclusion Drugs for the treatment of thromboangiitis obliterans were based on the“blood stasis”pathogenesis,with promoting blood circulation and removing blood stasis as the main treatment principle,which was supplemented by clearing heat,filling deficiency,warming,wind and spasmodic,pain relief,toxification of muscle,dryness,collaterals and other drugs.During the clinical application,it was adopted in the rule of flexible syndrome differentiation and treatment.
作者
张婧
李璇
刘明
孙庆
王玉涛
ZHANG Jing;LI Xuan;LIU Ming(The First Clinical College,Shandong University of Traditional Chinese Medicine,Jinan(250014),China)
出处
《中国中西医结合外科杂志》
CAS
2020年第5期850-857,共8页
Chinese Journal of Surgery of Integrated Traditional and Western Medicine
基金
山东省自然科学基金资助项目(ZR2017MH038)
全国名老中医药专家传承工作室建设项目(国中医药人教发〔2016〕42号)
山东省名老中医药专家传承工作室建设项目(鲁卫中发展字〔2018〕1号)
山东省中医药科技发展计划(2017-299)
山东省中医药科技发展计划(2019-0559)
山东省中医药科技发展计划(2019-0303)
山东大学第二届优秀卫生计生人才培养项目(济卫科外发〔2018〕8号)
山东大学第三批“薪火传承231工程”培养项目(济中医药发〔2017〕11号)
山东大学卫生健康系统青年岗位能手培养项目(济卫发〔2019〕1号)
山东大学卫生健康委员会科技计划项目(2019-1-23)。
