摘要
为评价咪达普利对中国高血压病人的降压疗效及安全性。方法：我们采用２：１开放型序贯法，以依那普利为对照，把２０６例病人随机分为咪达普利组（ １３６例）与依那普利组（７０例），进行了 ４～ ６周的诊室血压和 ２４ｈ动志血压观察。结果：发现 ５－ １０ ｍｇ咪达普利可以有效降低高血压病人的血压，降压作用可持续 ２４ｈ。降压的总有效率为９４．８％。药物的谷／峰比值大于５０％。咳嗽的发生率为５．１％，明显低于对照组。结论：中国轻、中型高血压病病人短期使用咪达普利（每天 ５－ １０ ｍｇ）安全、有效，药物不良反应少。
OBJECTIVE: To assess the antihypertensive effects and safety of imidapril in Chinese patients with mild to moderate essential hypertension. METHODS: The official or/and 24-hour ambulatory blood pressure were investigated in 206 patients with mild to moderate essential hypertension for 4-6 weeks. 136 subjects received imidapril, and the others were given enalapril as a control. Open type sequential method was used in the clinical trial. RESULTS: The data showed that increased blood pressure were controlled by 5- 10mg imidapril. The antihypertensive effect of imidapril can cover over 24 hours. Normotension was achieved in 94.8%. The trough to peak ratios for systolic and diastolic blood pressures by imidapril were all more than 50%. Cough occurred in 5. 1 % patients with imidapril, which is significantly lower than that with enalapril. CONCLUSION: In conclusion, once-daily dosing of imidapril (5-10 mg) is effective and safe to Chinese hypertensive patients with mild to moderate essential hypertension.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2000年第4期255-258,共4页
The Chinese Journal of Clinical Pharmacology
