摘要
为了进一步评价头孢呋辛钠治疗细菌性感染的安全性，有效性及药物不良反应。方法：开放试验７１５例，每次１．５９，每日二次，静点，重度患者每次３．０ｇ，每日二次。手术后预防细菌感染，每日一次，每次１．５Ｇ静点。结果：头孢呋丰钠治疗呼吸道感染痊愈率６５．０６％，有效率８８．８６％，有效率１００％，中度为９６．４３％，重度为６８．３７％。泌尿道感染痊愈率６２．９６％，有效率８６．６７％，轻度为１００％，中度为９３．９４％，重度为７０．２１％；其它感染痊愈率６７．３１％，有效率８９．４２％。轻度有效率为１００％，中度为９５．１６％，重度为６５．２２％。头孢呋辛钠手术预防用药，有效率达１００％。其细菌总清除率为８８．８７％，药物不良反应发生率为４．５％。结论：头孢呋辛钠治疗呼吸道感染、泌尿道感染、其他感染及手术后预防细菌感染疗效确切，药物不良反应少而轻。
OBJECTIVE : To evaluate the clinical efficacy and safty of cefuroxime sodium. METHODS: An open labeled multi-center clinical trial was conducted for the treatment of 715 patients with bacterial infections. Cefuroxime sodium as a trial drug was administrated 1 .5 g doses for mild to moderate infections and preventive infections after operation and 3.0g doses for severe infections.Both were twice a day by iv infusion.The treatment last 7- 14 days. RESULTS: The results showed the clinical cure rates of respiratory tract infections, urinary tract infections and other infections were 65.06%,62.96% and 67.31 % respectively. The clinical effective rates of respiratory tract infections, urinary tract infections and other infections were 88.86%,86.67% and 89.42% respectively.The bacterial clearance rates were 88.87%. The adverse drug reaction rates were 5.6%. CONCLUSION : Cefuroxime is a safe and effective drug in the treatment of infections of respiratory tract, urinary tract and other infections.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2000年第4期251-254,共4页
The Chinese Journal of Clinical Pharmacology
