摘要
细胞色素（CYP）P4502D6是最有多态性的酶系，主要参与心血管药物、抗精神病药物等的代谢。基因突变可以引起酶活性异常及水平的差异，最终造成人类对药物反应的个体差异。利用多聚酶链反应和限制性片段长度多态性分析等技术可以检测细胞色素2D6的基因型，而探针则可以检测其表型，将人群分为超强代谢者、强代谢者和弱代谢者。对细胞色素2D6的深入研究将有助于临床上治疗方案的个体化，减少或避免药物不良反应的发生。
Cytochrome P450 2D6 is a highly polymorphic enzyme in the human. It mainlymetabolizes cardiovascular drugs and antipsychotic drugs.The mutation of CYP 2D6 allelesleads to the variation of enzyme activities and levels, which accounts for the individualizationof drug effects. By the use of polymerase chain reaction (PCR) and restriction fragmentlength polymorphism (RFLP) assays we can distinguish the different genotype of CYP 2D6Probe-based assays can predict the phenotype of CYP 2D6 as ultrarapid metabolizer, extensivemetabolizers and Poor metabolizers. The further studies of CYP2D6 will aid in individualizedtherapy in clinical practice and reduce or avoid advcrse drug reactions in chemotherapy.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2000年第3期225-227,共3页
The Chinese Journal of Clinical Pharmacology
