摘要
目的探讨心脏副神经节瘤的临床病理特征及鉴别诊断。方法对1例心脏副神经节瘤进行组织学观察、免疫组化染色和临床随访,并复习相关文献。结果肿瘤组织呈器官样结构,肿瘤细胞由主细胞及支持细胞构成。免疫组化:肿瘤细胞vimentin、S-100、CD56、CgA、Syn(+),而CK、CD68、GFAP(-),Ki-67阳性指数约5%。术后2年零3个月,无复发。结论心脏的副神经节瘤是罕见的副神经节肿瘤,组织病理学特点结合免疫组化标记有助于该肿瘤的诊断。
Objective To investigate the clinicopathologic features and differential diagnosis of cardiac paraganglioma.Methods One case of cardiac paraganglioma was observed histologically,with immunohistochemical staining and clinical follow-up,and the related literature was reviewed.Results Histologically,the tumor showed organ-like structure,and the tumor cells were composed of main cells and supporting cells.Immunohistochemical staining showed that the tumor cells were positive for Vim,S100,CD56,CGA and Syn,while CK,CD68 and GFAP were negative.The positive index of Ki-67 was about 5%.2 years and 3 months postoperatively,there was no recurrence.Conclusion Cardiac paraganglioma is a rare paraganglioma,and its histopathologic features combined with immunohistochemical markers are helpful in the diagnosis of this tumor.
作者
赵华
王凯
王鸿雁
郑建杰
ZHAO Hua;WANG Kai;WANG Hong-yan;ZHENG Jian-jie(Department of Pathology,the First Affiliated Hospital of Xi’an Jiaotong University,Xi'an 710061,China;Department of Cardiouascular Surgery,the First Affiliated Hospital of Xi’an Jiaotong University,Xi'an 710061,China)
出处
《诊断病理学杂志》
2020年第8期564-566,572,共4页
Chinese Journal of Diagnostic Pathology
关键词
心脏副神经节瘤
嗜铬细胞瘤
临床病理
免疫组化
Cardiac Paraganglioma
Pheochromocytoma
Clinical pathology
Immunohistochemistry
