摘要
目的探讨孕期母体乙型肝炎病毒(HBV)载量与子代HBV宫内感染的关系。方法选取2015年2月至2018年3月成都市电子科技大学医学院附属妇女儿童医院(成都市妇女儿童中心医院)正常产检、完整建档及分娩的130例HBV感染产妇及其新生儿的临床资料作为研究对象。选择产前筛查中携带HBV的130例产妇,采血检测HBV感染血清学模式,所有产妇产后均采集新生儿脐带血,检测HBV感染及病毒载量,统计宫内感染率,采用Pearson相关分析法分析孕期母体HBV载量与子代HBV宫内感染的关系。结果130例携带HBV产妇宫内感染14例,感染率为10.77%,感染率从高到底依次为:1+3+5模式组>其他组>1+4+5模式组,但经检验差异无统计学意义(P>0.05);HBV-DNA载量≥10^5 copies/ml产妇宫内感染率高于HBV-DNA载量10^3 copies/mL^10^5 copies/mL、<10^3 copies/ml者,差异具有统计学意义(P<0.05);宫内HBV感染新生儿HBV-DNA载量高于未感染组,差异具有统计学意义(P<0.05);孕期HBV-DNA载量与子代HBV宫内感染率呈正相关,差异具有统计学意义(r=0.689,P<0.05)。结论产妇母体携带HBV可增加子代HBV宫内感染风险,HBV-DNA载量越高,宫内感染风险越大。
Objective To explore the relationship between maternal hepatitis B virus(HBV) load during pregnancy and HBV intrauterine infection of offspring. Methods 130 pregnant women with HBV carrier in prenatal screening were selected. Blood was collected for serological model of HBV infection. The neonatal cord blood was collected, the HBV infection and viral load was detected, and intrauterine infection rate was counted.Pearson correlation analysis was used to analyze the relationship between maternal HBV load and HBV intrauterine infection of offspring. Results There were 14 cases of intrauterine infection among pregnant women with HBV infection carrier, and the infection rate was 10.77%. The infection rate was the highest in mode 1+3+5 group and the lowest in mode 1+4+5 group, without statistically significant differences(P>0.05). The intrauterine infection rate of pregnant women with HBV-DNA load≥105 copies/ml was higher than that of pregnant women with HBV-DNA load 10^3~10^5 copies/ml and<10^3 copies/ml, with statistically significant differences(P<0.05). The HBV-DNA load of neonates with HBV intrauterine infection was higher than that of uninfected neonates, with statistically significant differences(P<0.05). The HBV-DNA load during pregnancy was positively correlated with HBV intrauterine infection rate, with statistically significant differences(r=0.689,P<0.05). Conclusions Maternal HBV carrier in pregnant women can increase the risk of HBV intrauterine infection of offspring, and the higher the HBV-DNA load, the greater the risk of intrauterine infection.
作者
方敏
龚春竹
李秀军
FANG Min;GONG Chunzhu;LI Xiujun(Department of Gynecology,Women's and Children's Hospital Affiliated to Medical College of Chengdu University of Electronic Science and Technology(Chengdu Women's and Children's Central Hospital),Chengdu 610091,Sichuan,China;Department of Pediatrics,Women's and Children's Hospital Affiliated to Medical College of Chengdu University of Electronic Science and Technology(Chengdu Women's and Children's Central Hospital),Chengdu 610091,Sichuan,China)
出处
《中国性科学》
2020年第8期84-87,共4页
Chinese Journal of Human Sexuality
关键词
孕期
乙肝病毒
感染
母婴传播
子代
Pregnancy
Hepatitis B virus(HBV)
Infection
Mother-to-child transmission
Offspring
