摘要
目的:观察左氧氟沙星联合抗结核化疗方案治疗复治涂阳肺结核患者的效果.方法:选取62例复治涂阳肺结核患者为研究对象,按照随机数字表法分为对照组与观察组各31例,对照组采用抗结核化疗方案(异烟肼+利福平+吡嗪酰胺)治疗,观察组在对照组基础上联合左氧氟沙星治疗,治疗9个月后,比较两组临床疗效(痰菌转阴率、空洞闭合率、治疗总有效率、不良反应发生率).?结果:治疗后,观察组痰菌转阴率、空洞闭合率、治疗有效率均高于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率为12.90%,与对照组的9.68%比较,差异无统计学意义(P>0.05).结论:左氧氟沙星联合抗结核化疗方案治疗复治涂阳肺结核患者可提高痰菌转阴率、空洞闭合率和治疗总有效率的效果优于单纯常规抗结核化疗方案治疗效果.
Objective:To evaluate effects of Levofloxacin combined with anti-tuberculosis chemotherapy regimen in treatment of smearpositive pulmonary tuberculosis.Methods:62 retreated smear-positive pulmonary tuberculosis patients were selected as the research objects,and were divided into control group and observation group according to the random number table method,31 cases in each group.The control group was treated with anti-tuberculosis chemotherapy regimen(Isoniazid+Rifampicin+Pyrazinamide),while the observation group was treated with Levofloxacin on the basis of that of the control group.After 9 months of treatment,the clinical efficacy(sputum negative conversion rate,cavity closure rate,total clinical effective rate,and incidence of adverse reactions)were compared between the two groups.Results:After the treatment,the sputum conversion rate,cavity closure rate,and total clinical effective rate of the observation group were higher than those of the control group,and the differences were statistically significant(P<0.05).The incidences of adverse reactions in the observation group and the control group were 12.90%and 9.68%,respectively,and the difference was not statistically significant(P>0.05).Conclusions:Levofloxacin combined with anti-tuberculosis chemotherapy regimen in the treatment of the retreated smear-positive pulmonary tuberculosis patients can improve the sputum negative conversion rate,the cavity closure rate and the total clinical effective rate.Moreover,it is superior to single anti-tuberculosis chemotherapy regimen.
作者
吴浩宇
WU Haoyu(Students and Children Tuberculosis Department of Shenyang Tenth People’s Hospital(Shenyang Chest Hospital),Shenyang 110044 Liaoning,China)
出处
《中国民康医学》
2020年第15期13-15,共3页
Medical Journal of Chinese People’s Health
关键词
复治涂阳肺结核
左氧氟沙星
抗结核化疗方案
痰菌转阴率
空洞闭合率
Retreatment of smear-positive pulmonary tuberculosis
Levofloxacin
Anti-tuberculosis chemotherapy regimen
Sputum negative conversion rate
Cavity closure rate
