摘要
目的观察耳穴贴压联合针刺防治乳腺癌术后化疗导致的恶心呕吐(CINV)的临床疗效。方法将92例乳腺癌术后化疗患者按照随机数字表法分为2组,对照组46例予盐酸托烷司琼注射液静脉滴注,治疗组46例在对照组治疗基础上予耳穴贴压联合针刺治疗。比较2组临床疗效及化疗期间恶心呕吐的控制率,急性呕吐、迟发性呕吐发生率;比较2组恶心、呕吐程度,治疗前后焦虑自评量表(SAS)评分。结果治疗组总控制率91.30%(42/46),对照组总控制率71.74%(33/46),治疗组总控制率高于对照组(P<0.05)。治疗组化疗期间迟发性呕吐发生率和呕吐总发生率分别为21.74%(10/46)、34.78%(16/46),均低于对照组的36.96%(17/46)、52.17%(24/46)(P<0.05)。2组化疗期间恶心及呕吐程度随着治疗天数增加而不断减轻,第2、3、5 d恶心程度轻于对照组(P<0.05),第3、5 d呕吐程度轻于对照组(P<0.05)。治疗后2组SAS评分均较本组治疗前降低(P<0.05),且治疗组低于对照组(P<0.05)。结论耳穴贴压联合针刺防治乳腺癌术后CINV疗效确切,尤其防治迟发性呕吐、改善患者化疗期间焦虑状态优势明显。
Objective To observe the effect of auricular point sticking combined with acupuncture in the prevention and treatment of nausea and vomiting(CINV)caused by chemotherapy after breast cancer surgery.Methods Ninety two patients receiving postoperative chemotherapy of breast cancer were randomly divided into two groups according to the random number table method.46 patients in the control group were given tropisetron hydrochloride injection by intravenous drip.46 patients in the treatment group were treated by auricular point sticking and acupuncture on the basis of the control group.The clinical efficacy,control rate of nausea and vomiting as well as the incidence of acute vomiting and delayed vomiting of patients during chemotherapy in two groups were compared;and the degree of nausea and vomiting and scores of self-rating anxiety scale(SAS)of patients in two groups were compared.Results The total control rate of nausea and vomiting in the treatment group was 91.30%(42/46),and such index in the control group was 71.74%(33/46).The total control rate of the treatment group was higher than that of the control group(P<0.05).The total incidence of delayed vomiting and vomiting in the treatment group during chemotherapy was 21.74%(10/46)and 34.78%(16/46)respectively.such indexes in the control group was 36.96%(17/46)and 52.17%(24/46),the treatment group was lower than the control group(P<0.05).The incidence of nausea and vomiting in the treatment group decreased with the increase of treatment days.The nausea degree of the treatment group was lighter than that of the control group on the second,third and fifth days(P<0.05),and the vomiting degree on the third and fifth days was lighter than that of the control group(P<0.05).After treatment,SAS scores of the two groups were lower than that in the group before treatment(P<0.05),and the treatment group was lower than the control group(P<0.05).Conclusion Auricular point sticking combined with acupuncture is effective in the prevention and treatment of postoperative CINV of breast cancer,especially in the prevention and treatment of delayed vomiting and improvement of patients'anxiety during chemotherapy.
作者
李雪英
王春煦
计彦新
张亚丽
董兴娟
潘分乔
LI Xueying;WANG Chunxu;JI Yanxin(Department of Internal Medicine,Xingtai Hospital of Traditional Chinese Medicine,Xingtai,Hebei 054000;不详)
出处
《河北中医》
2020年第6期917-921,共5页
Hebei Journal of Traditional Chinese Medicine
基金
河北省中医药管理局2014年度中医药类科研计划课题(编号:2014034)。
关键词
乳腺肿瘤
抗肿瘤联合化疗方案
恶心
呕吐
耳穴贴压
王不留行
针刺疗法
Breast cancer
Anti-tumor combined chemotherapy protocol
Nausea
Vomiting
Auricular point plastering and pressing,Vaccaria segetalis
Acupuncture therapy
