摘要
目的:观察葛根芩连汤治疗感染性腹泻对血清内毒素(ET)、可溶性白细胞分化抗原14(sCD14)水平及大便病原学的影响。方法:选取2018年5月至2020年5月辽宁省人民医院收治的感染性腹泻患者150例作为研究对象,按照随机数字表法随机分为对照组和观察组,每组75例。对照组给予诺氟沙星治疗,观察组在对照组基础上给予葛根芩连汤,均治疗3 d。评定2组治疗后疗效、大便正常率及病原学转阴率;比较2组治疗前后血清肠壁损伤因子、炎性反应因子水平。结果:治疗后,观察组总有效率(98.67%)高于对照组(89.33%,P<0.05);与治疗前比较,治疗后2组血清ET、D-乳酸(D-LA)、一氧化氮(NO)、sCD14、肿瘤坏死因子-α(TNF-α)、白细胞介素6(IL-6)水平均降低,且观察组低于对照组(P<0.05);治疗后,观察组大便正常率(94.67%)及病原学转阴率(92.00%)均高于对照组(82.67%、80.00%,P<0.05)。结论:葛根芩连汤治疗感染性腹泻可降低血清ET、sCD14水平,抑制肠壁损伤及炎性反应,同时促进大便病原学转阴,疗效确切。
Objective:To observe the effects of Gegen Qinlian Decoction on serum endotoxin(ET),levels of soluble leukocyte differentiation antigen 14(sCD14)and stool etiology.Methods:A total of 150 patients with infectious diarrhea admitted to Liaoning Provincial People′s Hospital between May 2018 and May 2020 were selected as the research objects and randomly divided into an observation group(75 cases)and a control group(75 cases)by random number table method.The control group was treated with norfloxacin,and the observation group was treated with Gegen Qinlian Decoction on the basis of the control group.Both groups were treated for 3 d.The clinical efficacy,normal stool rate,and the rate of etiology turning negative after treatment were evaluated.Serum intestinal wall injury factor and inflammatory factor were compared between the 2 groups before and after treatment.Results:After treatment,the total effective rate of the observation group(98.67%)was higher than the control group(89.33%,P<0.05);After treatment,the serum ET,D-lactic(D-LA)acid,nitric oxide(NO),sCD14,tumor necrosis factor-α(TNF-α),interleukin 6(IL-6)levels of the 2 groups decreased,and the observation group were lower than the control group(P<0.05);after treatment,the normal stool rate(94.67%)and the rate of etiology turning negative(92.00%)were higher than those in the control group(82.67%,80.00%,P<0.05).Conclusion:Gegen Qinlian Decoction in the treatment of infectious diarrhea can reduce the levels of serum ET and sCD14,inhibit the intestinal wall damage and inflammatory reaction,and at the same time promote the conversion of stool etiology turning to negative,with exact curative effects.
作者
姜东旭
白鸽
李偲
JIANG Dongxu;BAI Ge;LI Cai(Infectious Diseases Division,Liaoning Provincial People′s Hospital,Shenyang 11000,China;Liaoning University of Traditional Chinese Medicine,Shenyang 110000,China)
出处
《世界中医药》
CAS
2020年第17期2617-2619,2624,共4页
World Chinese Medicine
基金
辽宁省中医药科研项目(ZBY18-069)。
关键词
葛根芩连汤
感染性腹泻
内毒素
血清可溶性白细胞分化抗原14
病原学转阴
Gegen Qinlian Decoction
Infectious diarrhea
Endotoxin
Serum soluble leukocyte differentiation antigen 14
Stool etiology turning negative
