摘要
目的探讨熊去氧胆酸(ursodeoxycholic acid,UDCA)治疗原发性胆汁性胆管炎(primary biliary cholangitis,PBC)的疗效,为临床治疗提供参考。方法选择60例PBC患者为研究对象,采用自身对照方法,比较接受UDCA治疗前后应答率、生化指标变化。结果UDCA治疗1年后,Ⅱ期、Ⅲ期、Ⅳ期PBC患者巴黎与巴塞罗那评价结果差异有显著性(P<0.05);碱性磷酸酶(ALP)、γ-谷氨酰转肽酶(γ-GT)、总胆红素(TBIL)、丙氨酸氨基转移酶(ALT)及天冬氨酸氨基转移酶(AST)较治疗前均明显改善(P<0.05)。结论UDCA治疗早期PBC患者生化应答率较高。对早期识别生化应答不佳的PBC患者,应及时给予二线药物治疗。
Objective To investigate the efficacy of ursodeoxycholic acid(UDCA)in the treatment of primary biliary cholangitis(PBC)and to provide reference for clinical treatment.Methods A total of 60 patients with PBC were selected as the research objects.The response rate and biochemical indexes before and after UDCA treatment were compared by self-control method.Results After one-year treatment with UDCA,there were significant differences between Paris and Barcelona evaluation results of stage II,stage III and stage IV PBC patients(P<0.05).Indexes of Alkaline phosphatase(ALP),gamma-glutamyl transpeptidase(γ-GT),total bilirubin(TBIL),alanine aminotransferase(ALT)and aspartate aminotransferase(AST)significantly improved compared with those before treatment(P<0.05).Conclusion The response rate of PBC patients in the early stage of UDCA treatment was higher.Patients with PBC with poor early identification biochemical response should be treated with second-line drugs in time.
作者
赵素斌
张小芳
李守霞
胡永军
付彩文
崔庆丰
赵建红
张子龙
ZHAO Su-bin;ZHANG Xiao-fang;LI Shou-xia;HU Yong-jun;FU Cai-wen;CUI Qing-feng;ZHAO Jian-hong;ZHANG Zi-long(Affiliated Hospital of Hebei Engineering University,Handan,Hebei 056029,China;Handan Central Hospital,Handan,Hebei 056001,China;Shexian County Hospital,Handan,Hebei 056400,China)
出处
《河北北方学院学报（自然科学版）》
2020年第10期16-18,共3页
Journal of Hebei North University:Natural Science Edition
基金
邯郸市科技局科技计划与发展项目(No.16232080603)。
