摘要
目的:研究血清总胆汁酸在肝胆管结石患者手术前后的变化及预后评价价值。方法:抽取2016年10月15日-2018年10月15日笔者所在医院确诊为肝胆管结石患者100例作为本次研究对象,观察术前及术后血清总胆汁酸水平。将术后血清总胆汁酸水平作为分组依据,10.0 μmol/L<血清总胆汁酸水平<20.0 μmol/L记为A组,血清总胆汁酸水平≥20.0 μmol/L记为B组,比较两组预后情况。结果:100例患者术后血清总胆汁酸水平显著低于术前,差异有统计学意义(P<0.05)。术后1年,A组复发结石2例,复发胆管炎1例,复发率为4.62%;B组复发结石4例,复发胆管炎2例,复发率为17.14%;A组术后1年复发率显著低于B组,差异有统计学意义(P<0.05);术后30 d,A组生活质量评分明显高于B组,差异有统计学意义(P<0.05)。结论:血清总胆汁酸可作为评估肝胆管结石患者预后情况的指标之一。
Objective:To study the changes of serum total bile acid in patients with hepatolithiasis before and after operation and the value of prognosis evaluation.Method:A total of 100 patients diagnosed with hepatolithiasis from October 15,2016 to October 15,2018 were selected as the subjects of this study to observe the serum total bile acid levels before and after operation.Postoperative serum total bile acid level was used as the basis of grouping,and the serum total bile acid level was greater than 10μmol/L and less than 20μmol/L as the group A,and the serum total bile acid level was greater than or equal to 20.0μmol/L as the group B.The prognosis of the two groups was compared.Result:The postoperative serum total bile acid level of 100 patients was significantly lower than that before operation,and the difference was statistically significant(P<0.05).One year after the operation,there were 2 cases of recurrent calculi and 1 case of recurrent cholangitis in the group A,and the recurrence rate was 4.62%.And there were 4 cases of recurrent calculi and 2 case of recurrent cholangitis in the group B,and the recurrence rate was 17.14%.The recurrence rate of the group A was significantly lower than the group B,and the difference was statistically significant(P<0.05).And 30 days after the operation,the quality of life scores of the group A were significantly higher than those of the group B,and the differences were statistically significant(P<0.05).Conclusion:Serum total bile acid can be used as an indicator to evaluate the prognosis of patients with hepatolithiasis.
作者
陈达
王智波
王旭光
CHEN Da;WANG Zhibo;WANG Xuguang(Zhanjiang Agricultural Reclamation Second Hospital in Guangdong,Zhanjiang 524000,China;不详)
出处
《中外医学研究》
2020年第22期66-67,共2页
CHINESE AND FOREIGN MEDICAL RESEARCH
基金
2018年度湛江市第三批非资助科技攻关计划项目(2018B01141)。
关键词
血清总胆汁酸
肝胆管结石
手术前后
预后评价
生活质量
Serum total bile acid
Hepatolithiasis
Before and after operation
Prognosis evaluation
Quality of Life
