摘要
K-Cl协同转运蛋白(KCC)2调节K^+和Cl^-离子跨膜转运,在细胞容积和离子稳态调节中发挥作用。KCC2活性丧失与多种疾病有关,包括癫痫和脊髓损伤后的痉挛等,是相关神经疾病的理想药物靶点。本文探讨KCC2与脊髓损伤相关的痉挛和癫痫的关联、KCC2参与相关神经系统疾病的作用机制和在相关治疗中的进展。
K-Cl cotransporters(KCC) 2 regulates the transmembrane transport of K^+ and Cl^- ions and plays a role in the regulation of cell volume and ion homeostasis. Loss of KCC2 activity has been linked to a variety of diseases, including epilepsy and spasms after spinal cord injury, and it is an ideal drug target for the treatment of related nervous diseases. This paper discusses the association between KCC2 and spasm and epilepsy related to spinal cord injury, the mechanism of action of KCC2 in related nervous system diseases and the progress in related treatment.
作者
程颖颖
赖国钢
金力
刘胜兵
CHENG Ying-ying;LAI Guo-gang;JIN Li(School of Medicine,Jiaxing University,Jiaxing 314001,China)
出处
《临床神经病学杂志》
CAS
2020年第4期315-319,共5页
Journal of Clinical Neurology
基金
浙江省公益技术应用研究项目(2017C37114)
嘉兴学院SRT项目(851719493)。
关键词
KCC2
脊髓损伤痉挛
癫痫
K-Cl cotransporters 2
spasm related to spinal cord injury
epilepsy
