摘要
目的:探索β2微球蛋白对于弥漫大B细胞淋巴的临床价值。方法:回顾性分析弥漫大B细胞淋巴瘤病人共102例,记录病人初诊年龄、性别、Ann Arbor分期、乳酸脱氢酶和β2微球蛋白血清水平、有无B组症状和ECOG评分,按照国际预后指数(IPI)、国家综合癌症网络预后指数(NCCN-IPI)评分标准分组后进行统计学分析。结果:各组β2微球蛋白水平升高例数差异有统计学意义(P<0.01);随着预后危险等级升高,β2微球蛋白水平逐渐升高,且高危组β2微球蛋白水平明显高于低危组和低中危组(P<0.01)。logistic回归分析显示β2微球蛋白水平升高是IPI和NCCN-IPI预后分组的危险因素(P<0.01)。β2微球蛋白和乳酸脱氢酶无相关性,与是否结外受累无明显相关性(r=-0.115,P>0.05),与年龄、肿瘤分期、ECOG评分呈相关关系(r=0.249、0.464、-0.357,P<0.05)。结论:β2微球蛋白水平升高可能是影响弥漫大B淋巴瘤病人预后的危险因素之一,其相关机制有待进一步研究。
Objective:To explore the clinical value ofβ2 microglobulin in diffuse large B cell lymphoma.Methods:The clinical data of 102 patients with diffuse large B cell lymphoma were retrospectively analyzed.The age at first diagnosis,gender,Ann Arbor stage,serum levels of lactate dehydrogenase and hypoglobulin,with and without group B symptoms and ECOG scores of patients were recorded.According to the international prognostic index(IPI)and national comprehensive cancer cefter international prognostic index(NCCN-IPI)scoring criteria,the data of patient were statistically analyzed.Results:The difference of the number of cases with increasing microglobulin level among different groups was statistically significant(P<0.01).With the increasing of prognostic risk level,the level ofβ2 microglobulin increased gradually,and the level ofβ2 microglobulin in high-risk group was significantly higher than that in low-risk group and medium-risk group(P<0.01).The results of logistic regression analysis showed that the increasing ofβ2 microglobulin level was a risk factor of IPI and NCCN-IPI prognosis grouping(P<0.01).The correlation analysis showed thatβ2 microglobulin was not correlated with lactic dehydrogenase and external node involvement(P>0.05),andβ2 microglobulin was correlated with the age,tumor stage and ECOG score(P<0.05).Conclusions:The level increasing ofβ2 microglobulin may be one of the risk factors of patients with diffuse large B lymphoma,and the related mechanism of which needs to be further studied.
作者
于明雪
刘加军
YU Ming-xue;LIU Jia-jun(Department of Hematology,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou Guangdong 510630,China)
出处
《蚌埠医学院学报》
CAS
2020年第8期1040-1043,共4页
Journal of Bengbu Medical College
基金
广东省广州市科技创新计划项目(201508020258)。
关键词
弥漫大B细胞淋巴瘤
Β2微球蛋白
国际预后指数
diffuse large B cell lymphoma
β2 microglobulin
international prognostic index
