摘要
目的:检测宫颈癌组织中ERRα和ERRβ的表达水平,并分析其临床意义。方法:收集2015年3月-12月我院宫颈癌手术切除的肿瘤标本47例,同期收集子宫全切宫颈无病变患者正常子宫颈组织30例为对照组,采用免疫组化法检测所有组织样本中ERRα和ERRβ表达水平,同时分析二者与宫颈癌临床病理特征、预后的相关性,并研究二者之间存在的关系。结果:宫颈癌组织ERRα、ERRβ蛋白阳性表达率(70.21%,74.47%)均明显高于正常宫颈组织ERRα、ERRβ蛋白阳性表达率(29.79%,31.91%),差异有统计学意义(P<0.05);宫颈癌组织中ERRα和ERRβ蛋白阳性表达与患者年龄、淋巴结转移及病理类型均无关(P>0.05),与临床分期(FIGO,2019年)、肿瘤分化程度、浸润深度均有关(P<0.05);ERRα和ERRβ蛋白阳性表达患者总生存期明显短于ERRα和ERRβ蛋白阴性表达患者(t=5.325,P=0.024);经Logistic单变量回归分析发现,患者年龄、淋巴结转移、FIGO分期、肿瘤分化程度、病理类型、浸润深度、ERRα及ERRβ蛋白阳性表达均与患者预后有关(P<0.05);多因素分析发现,FIGO分期、淋巴结转移、ERRα和ERRβ蛋白阳性表达为患者预后的独立预测指标。结论:ERRα和ERRβ在宫颈癌组织中高表达,与宫颈癌患者临床病理特征及不良预后存在一定相关性,二者联合检测对宫颈癌患者预后有一定预测作用。
Objective To detect the expression of ERRαand ERRβin cervical cancer tissues and analyze their clinical sig⁃nificance.Methods 47 cases of tumor specimens were collected from cervical cancer surgical resection in our hospital from March 2015 to December 2015.At the same time,30 cases of normal cervical tissue were collected from the uterus without cervix.The expression levels of ERRαand ERRβin all tissue samples were detected by immunohistochemistry.The correla⁃tion between them and the clinicopathological features and prognosis of cervical cancer were analyzed,and the relationship between them was studied.Results The positive expression rates of ERRαand ERRβprotein in cervical cancer tissues(70.21%,74.47%)were significantly higher than those in normal cervical tissues(29.79%,31.91%),and the difference was statistically significant(P<0.05).The positive expression of ERRαand ERRβprotein in cervical cancer tissues was not correlated with age,lymph node metastasis and pathological type(P>0.05),and was associated with FIGO stage,tumor differentiation degree and depth of invasion(P<0.05).The overall survival time of patients with positive expression of ERRαand ERRβprotein was significantly shorter than that of patients with negative expression of ERRαand ERRβprotein(t=5.325,P=0.024).Logistic univariate regression analysis showed that age,lymph node metastasis,FIGO stage,tumor differentiation,pathological type,depth of invasion,ERRαand ERRβprotein positive expression were all related to the prognosis of patients(P<0.05).Multivariate analysis showed that FIGO stage,lymph node metastasis,ERRαand ERRβprotein positive expression were independent predictors of prognosis.Conclusion The high expression of ERRαand ERRβin cervical cancer tissues has certain correlation with clinicopathological features and poor prognosis of cervical cancer pa⁃tients.The combined detection of these two has a certain predictive effect on the prognosis of cervical cancer patients.
作者
张毅
龚宝兰
许莹平
范丽
李凯
马亚琳
ZHANG Yi;GONG Bao-lan;XU Ying-ping;FAN Li;LI Kai;MA Ya-lin(Department of gynecology,Shiyan,Hubei 442000,China;Department of pathology,Renmin Hospital,Hubei University of Medicine,Shiyan,Hubei 442000,China)
出处
《湖北医药学院学报》
CAS
2020年第4期358-361,370,F0004,共6页
Journal of Hubei University of Medicine
基金
十堰市科技局项目(18Y64)。
