摘要
慢性萎缩性胃炎(CAG)是临床中常见的消化系统疾病,众多研究表明针灸对CAG有确切疗效。胃黏膜组织的细胞凋亡被证实在CAG发生胃黏膜萎缩以及进一步癌变的过程中发挥重要作用,而环状RNA(circRNA)作为一类非编码RNA被证实在细胞凋亡中对下游凋亡通路起调节作用。相关研究证明细胞凋亡可以被针灸激活和调节,在治疗CAG时,针灸可以抑制胃黏膜的细胞凋亡。因此,circRNA在针灸对CAG胃黏膜细胞凋亡的抑制过程中发挥了潜在作用。本文通过系统梳理和论述circRNA对细胞凋亡的调节、CAG的细胞凋亡机制、针灸与细胞凋亡间的关系,提出circRNA极有可能参与了针灸治疗CAG的新研究思路。未来的研究可通过探寻相关circRNA及其涉及的下游靶蛋白,对针灸治疗CAG的机制进行深入探讨。
Chronic atrophic gastritis(CAG)is a common digestive disease in clinic.Previous experimental and clinical studies have shown that acupuncture has a positive effect for CAG.Apoptosis of gastric mucosal tissue has been shown to play an important role in the process of gastric atrophy and possibly further carcinogenesis in CAG,and the circular RNA(circRNA),a novel class of non-coding RNA,has been confirmed to play a regulatory role in the downstream pathway of apoptosis by many stu-dies.Accumulated findings of experimental studies showed that acupuncture and moxibustion interventions could suppress apoptosis of the cultured human gastric mucosal epithelial cells and lower apoptotic index of gastric mucosal cells in CAG rats.Therefore,circRNA is likely to mediate the inhibitory effect of acupuncture and moxibustion on apoptosis of gastric mucosal epithelial cells in CAG.In this paper,we systematically summarized 1)the regulation of circRNA on apoptosis,2)the apoptosis and pathological mechanism of CAG,3)the effect of acupuncture on apoptosis,and proposed that circRNA is highly likely to be involved in the positive effect of acupuncture and moxibustion interventions for CAG.It is recommended that researches should further reveal the scientific basis of acupuncture and moxibustion therapies in the treatment of CAG by exploring the role of related circRNAs and their downstream target proteins in the gastric mucosal tissues.
作者
侯瑜超
刘璐慜
陈晓桐
安晓菲
赵琛
李璟
HOU Yu-chao;LIU Lu-min;CHEN Xiao-tong;AN Xiao-fei;ZHAO Chen;LI Jing(Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200437,China;School of Acupuncture-moxibustion and Tuina,Shanghai University of Traditional Chinese Medicine,Shanghai 201203)
出处
《针刺研究》
CAS
CSCD
北大核心
2020年第8期676-681,共6页
Acupuncture Research
基金
国家自然科学基金项目(No.81674071)
上海市临床重点专科项目(No.shslczdzk04701)
上海市中医专科(专病)联盟建设项目[No.ZY(2018-2020)-FWTX-4008]。
关键词
慢性萎缩性胃炎
针灸
胃黏膜组织
凋亡
环状RNA
Chronic atrophic gastritis
Acupuncture-moxibustion
Gastric mucosal tissue
Apoptosis
Circular RNA
