摘要
目的探究甲硝唑联合硝呋太尔治疗妊娠期滴虫性阴道炎的临床效果。方法选取我院收治的200例妊娠期滴虫性阴道炎患者,随机将其分为对照组(100例,甲硝唑片)和试验组(100例,甲硝唑片+硝呋太尔制霉素阴道软胶囊)。比较两组患者的治疗效果。结果试验组的治疗总有效率为98.00%,明显高于对照组的81.00%(P<0.05)。治疗后,两组的IL-2、IL-8、C反应蛋白水平均降低,且试验组低于对照组(P<0.05)。治疗后,两组的阴道pH均降低,生活满意度评分均升高,且试验组明显优于对照组(P<0.05)。两组的不良反应总发生率比较,差异无统计学意义(P>0.05);试验组复发率为2.00%,明显低于对照组的19.00%(P<0.05)。结论甲硝唑联合硝呋太尔治疗妊娠期滴虫性阴道炎的临床效果显著,可减轻患者炎症反应,增加生活满意度,降低复发率,且安全性较好。
Objective To explore the clinical effect of metronidazole combined with nifuratel in the treatment of trichomonas vaginitis during pregnancy.Methods A total of 200 patients with trichomonas vaginitis during pregnancy admitted in our hospital were selected and randomly divided into control group(100 cases,metronidazole tablets)and experimental group(100 cases,metronidazole tablets+nifuratel and nysfungin vaginal soft capsules).The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the experimental group was 98.00%,which was significantly higher than 81.00%in the control group(P<0.05).After treatment,the levels of IL-2,IL-8 and C-reactive protein in the two groups decreased,and those in the experimental group were lower than the control group(P<0.05).After treatment,the vaginal pH of the two groups decreased,the life satisfaction score increased,and those in the experimental group were significantly better than the control group(P<0.05).There was no significant difference in the total incidences of adverse reactions between the two groups(P>0.05).The recurrence rate in the experimental group was 2.00%,which was significantly lower than 19.00%in the control group(P<0.05).Conclusion Metronidazole combined with nifuratel in the treatment of trichomonas vaginitis during pregnancy has a significant clinical effect.It can reduce the inflammatory reaction of patients,increase life satisfaction,reduce the recurrence rate,and has better safety.
作者
张伟霞
耿晓卉
ZHANG Weixia;GENG Xiaohui(Xi'an Chang'an District Maternal and Child Health Planning Service Center,Xi'an 710100,China)
出处
《临床医学研究与实践》
2020年第23期87-89,共3页
Clinical Research and Practice
关键词
妊娠期
滴虫性阴道炎
硝呋太尔
甲硝唑
炎性因子
pregnancy
trichomonas vaginitis
nifuratel
metronidazole
inflammatory factors
