摘要
目的探讨应用低剂量甲状腺激素替代治疗方法对于老年重度慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)合并甲状腺功能减退患者生活质量及急性加重次数的影响。方法选取2017年8月-2018年12月浦东医院门诊治疗的老年重度COPD稳定期合并甲状腺功能减退患者80例,随机分为试验组(n=40)和对照组(n=40)。试验组患者口服左旋甲状腺素片,25 g/d;对照组患者口服淀粉片剂,25 g/d。治疗3个月后,评估并比较2组患者甲状腺功能、肺功能检测、慢性阻塞性肺疾病评估测试(CAT)评分以及治疗期间急性加重次数。结果治疗3月后,2组肺功能及甲状腺功能水平差异均无统计学意义(P>0.05),试验组CAT评分明显低于对照组(P<0.05),急性加重次数差异无统计学意义(P>0.05)。结论补充小剂量甲状腺激素可改善老年重度COPD稳定期合并甲状腺功能减退患者的生活质量。
Objective To investigate the effects of low-dose thyroid hormone replacement therapy on the quality of life and acute exacerbations in elderly patientswith severe chronic obstructive pulmonary disease(COPD)complicated with hypothyroidism.Methods 80 elderly patients with severe COPD in stable stage and hypothyroidismtreated in the outpatient department of our hospital from August 2017 to December 2018 were selected and randomly divided into experimental group(n=40)and control group(n=40).The patients in the experimental group were given oral levothyroxine tablets,25 g/d;while the patients in the control group were given starch tablets,25 g/d.After 3 months of treatment,thyroid function,lung function,chronic obstructive pulmonary disease assessment test(CAT)score and the number of acute exacerbations during the treatment were evaluated and compared between the two groups.Results After 3 months of the treatment,there was no significant difference in lung function,thyroid function and the number of acute exacerbations between the two groups(P>0.05),but the CAT score of the experimental group was significantly lower than that of the control group(P<0.05).Conclusions Low-dose thyroid hormone supplementation can improve the quality of life of elderly patients with severe COPD complicated with hypothyroidism.
作者
徐春燕
朱默然
朱先极
包红
王嘉漫
沈瑶
Xu Chunyan;Zhu Moran;Zhu Xanji;Bao Hong;Wang Jiaman;Shen Yao(Department of Pulmonary Medicine,Pudong Hospital Affiliated to Fudan University,Shanghai,201399,P.R.China)
出处
《老年医学与保健》
CAS
2020年第4期606-608,612,共4页
Geriatrics & Health Care
基金
上海市浦东新区重点专科项目(PWZzk2017-30)。
关键词
老年
慢性阻塞性肺疾病
甲状腺激素
肺功能
生活质量
elderly
chronic obstructive pulmonary disease
thyroid hormone
pulmonary function
quality of life
