摘要
癌症和脑血管病是我国发病率和病死率极高的两大疾病,同时罹患这两种疾病对患者而言可谓致命打击。近年来,癌症与动脉栓塞及血栓形成的联系逐渐引起关注,相继可见癌症患者缺血性卒中的危险因素、临床表现、生物学标志物及影像学特点等报道。然而,国内关于癌症相关缺血性卒中的认识尚不足,此类患者病因与潜在机制亦不明确,使得目前仍无统一的诊断标准、治疗及预防策略。因此,本文综述国内外关于癌症相关缺血性卒中的流行病学、临床与影像学特征、发病机制、治疗方案及预后的研究证据,旨在梳理癌症相关缺血性卒中的研究进展与差距,以及解决上述问题的潜在策略。
Nowadays,cancer and cardiovascular disease are great contributors to burden of disease with high morbidity and mortality in China.Being affected by both stroke and cancer can be devastating.The association between cancer and venous thrombosis has been previously well described.Recently,cancer has been considered to be increasingly related to arterial thromboembolism or thrombosis.Several studies have shown the characteristics of vascular risk factors,clinical manifestations,biomarkers and neuroimaging in patients with ischemic stroke and cancer.However,there is still insufficient recognition of cancer-associated ischemic stroke(CAIS)in our country.Moreover,the underlying mechanisms of CAIS are uncertain,which makes the optimal strategies to diagnose,treat and prevent ischemic stroke in cancer patients still unestablished.This review summarized the current research evidence on epidemiology,clinical and imaging characteristics,mechanism,treatments and prognosis in patients with CAIS,aiming to reveal the research progress and knowledge gaps,as well as the potential strategies to solve these problems.
作者
姜季委
陈昱彤
彭乾
亢迪
商秀丽
JIANG Ji-wei;CHEN Yu-tong;PENG Qian;KANG Di;SHANG Xiu-li(Department of Neurology,the First Affiliated Hospital of China Medical University,Shenyang 110001,Liaoning,China)
出处
《中国现代神经疾病杂志》
CAS
北大核心
2020年第4期359-365,共7页
Chinese Journal of Contemporary Neurology and Neurosurgery
基金
国家自然科学基金青年科学基金资助项目(项目编号:81871104)。
关键词
卒中
脑缺血
肿瘤
综述
Stroke
Brain ischemia
Neoplasms
Review
