OCT参数对视网膜静脉阻塞继发黄斑水肿抗VEGF疗法预后的预测价值被引量：9

Predictive value of OCT parameters to prognosis of anti-VEGF therapy for macular edema secondary to retinal vein occlusion

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摘要视网膜静脉阻塞(RVO)继发黄斑水肿是导致患者视功能损害的主要原因,目前玻璃体腔注射抗血管内皮生长因子(VEGF)药物是一线治疗方法,可以使大部分患者视网膜解剖结构及视功能得到改善。光相干断层扫描成像(OCT)能够清晰地显示黄斑区视网膜细微结构,对治疗前后黄斑区各组织层次结构的定性、定量分析可以指导临床治疗和预测RVO患者视力预后。就RVO在OCT上的表现,对影响抗VEGF治疗视力预后的相关因素,包括黄斑区视网膜厚度、外界膜和椭圆体带破坏、高反射病灶、视网膜内层结构紊乱、浆液性视网膜脱离或视网膜内囊腔、视网膜下出血、玻璃体黄斑粘连以及视网膜色素上皮(RPE)完整性破坏等进行综述,为患者咨询、风险评估以及治疗决策提供参考。 Macular edema secondary to retinal vein occlusion(RVO)is the leading cause of visual impairment in patients with RVO.Intravitreal injection of anti-vascular endothelial growth factor(VEGF)agents is the first-line treatment for RVO and most of patients can obtain improvements of macular morphology and visual function.Optical coherence tomography(OCT)can clearly characterize the macular microstructure.Qualitative or quantitative analysis of histological retinal layers of the macula,before and after anti-VEGF treatment,can guide the clinical treatment and predict visual outcome of patients with RVO.OCT predictors of visual prognosis in patients with RVO following anti-VEGF treatment,including central retinal thickness,disruption of external limiting membrane and ellipsoid zone,hyperreflective foci,disorganization of the retinal inner layers,serous retinal detachment or intraretinal cystoid spaces,subretinal hemorrhage,vitreomacular adhesion and retinal pigment epithelium(RPE)integrity are focused on in this review,aiming to enhance patient counseling and improve risk assessment and advance clinical management.

作者汤富生(综述) 卢建民马翔(审校) Tang Fusheng;Lu Jianmin;Ma Xiang(Department of Ophthalmology,The First Affiliated Hospital of Dalian Medical University,Dalian 116011,China)

机构地区大连医科大学附属第一医院眼科

出处《中华实验眼科杂志》 CAS CSCD 北大核心 2020年第7期625-628,共4页 Chinese Journal Of Experimental Ophthalmology

基金国家自然科学基金项目(81770970、81271022)。

关键词光相干断层成像视网膜静脉阻塞抗血管内皮生长因子预测因素 Tomography optical coherence Retinal vein occlusion Anti-vascular endothelial growth factor Predictive factors

分类号 R774.1 [医药卫生—眼科]

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1韩月圣,魏文斌.糖尿病性黄斑水肿视网膜微结构SD-OCT改变研究进展[J].国际眼科杂志,2015,15(4):625-629. 被引量：3

二级参考文献76

1Klein BE.Overview of epidemiologic studies of diabetic retinopathy. Ophthalmic Epidemiol 2007; 14(4): 179-183.
2Yau JWY, Rogers SL, Kawasaki R,et al. Global prevalence and major risk factors of diabetic retinopathy. Diabetes Care 2012; 35(3):556-564.
3Nicholson BP, Schachat AP. A review of clinical trials of anti-VEGF agents for diabetic retinopathy. Graefes Arch Clin Exp Ophthalmol 2010; 248(7):915-930.
4Klein R, Klein BE, Moss SE. Visual impairment in diabetes. Ophthalmology 1984; 91(1):1-9.
5Bhagat N, Grigorian RA, Tutela A,et al. Diabetic macular edema: pathogenesis and treatment. Surv Ophthalmol 2009; 54(1):1-32.
6Phillips RP, Ross PG, Tyska M,et al. Detection and quantification of hyper fluorescent leakage by computer analysis of fundus fluorescein angiograms. Graefes Arch Clin Exp Ophthalmol 1991; 229(4):329-335.
7Sander B, Larsen M, Moldow B, et al. Diabetic macular edema: passive and active transport of fluorescein through the blood-retina barrier. Invest Ophthalmol Vis Sci 2001; 42(2):433-438.
8Knudsen ST, Bek T, Poulsen PL, et al. Macular edema reflects generalized vascular hyperpermeability in type 2 diabetic patients with retinopathy. Diabetes Care 2002; 25(12):2328-2334.
9Murakami T, Nishijima K, Sakamoto A,et al. Foveal cystoid spaces are associated with enlarged foveal avascular zone and microaneurysms in diabetic macular edema. Ophthalmology2011; 118(2):359-367.
10Abu el Asrar AM, Maimone D, Morse PH,et al. Cytokines in the vitreous of patients with proliferative diabetic retinopathy. Am J Ophthalmol 1992; 114(6):731-736.