摘要
视网膜静脉阻塞(RVO)是一种引起视力减退的常见视网膜血管病,仅次于糖尿病性视网膜病变。RVO的病因复杂,发病机制尚未完全阐明,且病情易反复,治疗手段有限。随着现代医学技术的发展,RVO模型的诱导方法有许多。激光光凝法和光动力疗法(PDT)已成为制备RVO模型的主要方法。迄今,激光光凝法或PDT已成功在鼠、兔、猪和猴等多种动物中诱导出RVO模型,且不同动物模型的眼底可近似表现人类RVO的典型临床表征和组织病理学特征。此外,激光光凝法或PDT诱导的RVO模型有各自的优势与局限,尚缺乏标准的实验参数。就建立理想的RVO模型的方法以及该模型对人类RVO的病因学、病理学及药物干预研究的意义进行综述。
Retinal vein occlusion(RVO)is a common retinal vascular disease that causes vision loss.The etiology of RVO is complex and its pathogenesis has not yet been fully elucidated.With the development of modern medical technology,there are more and more methods to induce animal models of RVO.Laser photocoagulation and photodynamic therapy(PDT)are the main induction methods for animal models of RVO.Up to now,animal models of RVO have been successfully induced by laser photocoagulation or PDT in many animal species(e.g.,mouse,rabbit,pig and monkey).The fundus of different animals can exhibit clinical characterization and histopathological features that approximate those typical of human RVO.In addition,animal model of RVO induced by laser photocoagulation or PDT still lacks standard experimental parameters and has its own advantages and limitations.Therefore,methods of establishing an ideal animal model of RVO on the basis of previous experience,importance for the study of the etiology,pathology and drug intervention of human RVO are reviewed in this article.
作者
裴超(综述)
冯俊(审校)
Pei Chao;Feng Jun(Eye Hospital of China Academy of Chinese Medical Sciences,Beijing 100040,China)
出处
《中华实验眼科杂志》
CAS
CSCD
北大核心
2020年第7期621-624,共4页
Chinese Journal Of Experimental Ophthalmology
关键词
视网膜静脉阻塞
动物模型
激光光凝法
光动力疗法
Retinal vein occlusion
Animal model
Laser photocoagulation
Photodynamic therapy
