摘要
目的:探究大柴胡汤对热毒内结型脓毒症患者外周血炎症因子含量的影响。方法:将63例热毒内结型脓毒症患者随机分为对照组和治疗组,对照组31例,治疗组32例,两组患者均采用西医常规抗感染治疗,在此基础上,治疗组采用大柴胡汤治疗,疗程为3天。观察比较两组患者治疗前后APACHEⅡ评分、中医证候积分,以及外周血肿瘤坏死因子α、外周血C反应蛋白、外周血降钙素原、白细胞水平。结果:治疗组患者治疗后外周血中炎症因子含量、中医证候积分均显著下降,与对照组比较差异具有统计学意义(P<0.05)。结论:大柴胡汤能有效减轻热毒内结型脓毒症患者的炎症反应。
Objective:To explore the therapeutic effect and mechanism of Da-Chai-Hu Decoction on patients with sepsis.Methods:Sixty-three patients with sepsis were randomly divided into control group and treatment group,with 31 cases in control group and with 32 cases in treatment group,Both groups of patients were treated with conventional anti-infective treatment of Western medicine.On this basis,the treatment group was treated with Da Chai Hu Tang.The course of treatment is 3 days.Changes in APACHEⅡscore,TCM syndrome score,peripheral blood tumor necrosis factor alpha,peripheral blood C-reactive protein content,peripheral blood procalcitonin content,arterial oxygen partial pressure,and oxygenation index were observed and compared between the two groups of patients.Results:After treatment,the content of inflammatory factors and TCM syndrome scores in the peripheral blood of patients in the treatment group decreased significantly,and the difference was statistically significant compared with the control group(P<0.05).Conclusion:Da-Chai-Hu Decoction can effectively reduce the content of inflammatory cytokines in peripheral blood of patients with heat-toxic end-node sepsis.
作者
张仕娜
郑爱华
刘红梅
Zhang Shina;Zheng Aihua;Liu Hongmei(Hunan University of Traditional Chinese Medicine,Changsha 410208,China;the 2th affiliated hospital of Hunan University of Traditional Chinese Medicine,Changsha 410005,China)
出处
《亚太传统医药》
2020年第7期150-152,共3页
Asia-Pacific Traditional Medicine
基金
湖南省教育厅课题(18C0378)。
关键词
脓毒症
大柴胡汤
炎症因子
Sepsis
Da-Chai-Hu Decoction
Inflammatory Factor
