摘要
本文针对一种旋转式血泵的人工心脏在临床上应用于心衰患者时因恒定泵速导致主动脉瓣永久闭合的现象,以及血管搏动性明显降低的缺点,设计了一种新颖的反馈控制方法,用于提高主动脉瓣性能和血管搏动性.该方法设定主动脉与左心室压力差(△P)的高低参考值(△PH/△PL),采用增益调度PI控制器,使△P实际值逼近一个参考值后立即向另一个参考值逼近.仿真结果表明,此方法可以有效地提高血管搏动性、保证心输出量,并使得主动脉瓣间歇性开启的同时不引起抽吸和返流现象.本文设计的控制系统可为旋转式血泵的设计和优化提供理论依据和技术支持.
Rotary blood pumps(RBP)as one type of artificial hearts,are currently operated at a fixed pump speed(PS)for the heart failure(HF)patients in clinical.However,fixed-PS operating mode may make permanent closure for the aortic valve,and obviously diminish vascular pulsatility.To overcome the above limitations,this study presents a new feedback control system for RBPs to meet the objective of aortic valve opening,while simultaneously increasing vascular pulsatility.Based on the difference between the aortic pressure and the left ventricular pressure(△P),the proposed algorithm sets the high and low reference values(△PH/△PL).A gain-scheduled,proportional integral(PI)controller maintains the actually measured△P at a high△P setpoint(△PH),leading to high RBP flow.When the value of△P approaches to△PH,the controller automatically switches to a low△P setpoint(△PL)that reduces RBP flow and generates pulsatility.The in-silico results using a combined human circulatory system and RBP model show that the proposed control algorithm effectively increased vascular pulsatility and maintained adequate physiologic perfusion,while intermittently opening the aortic valve to make sure that ventricular suction and backflow did not occur for all test conditions.The proposed control system could provide theoretical basis and technology support for designing and optimizing the RBPs.
作者
王珺玮
蒋皓月
王宇
WANG Jun-wei;JIANG Hao-yue;WANG Yu(Faculty of Electronic Information and Electrical Engineering,Dalian University of Technology,Dalian Liaoning 116024,China;School of Optoelectronic Engineering and Instrumentation Science,Dalian University of Technology,Dalian Liaoning 116024,China)
出处
《控制理论与应用》
EI
CAS
CSCD
北大核心
2020年第7期1511-1520,共10页
Control Theory & Applications
基金
辽宁省“兴辽英才计划”青年拔尖人才项目(XLYC1807016)
中央高校基本科研业务费专项资金项目(DUT19JC38)
大连理工大学大学生创新创业训练计划项目(1300–81141301)资助。
关键词
人工心脏
旋转式血泵
主动脉瓣性能
血管搏动性
反馈控制
artificial heart
rotary blood pumps
aortic valve performance
vascular pulsatility
feedback control
