摘要
Recent days,aggregatable nanoparticles,which can specifically respond to certain stimulus,have shown great potential in tumor-targeted drug delivery with prolonged retention and deeper penetration.In this review,we summarize recent advances in design of aggregatable nanoparticles by different stimuli.Internal(pH and enzyme)and external(light,temperature and ROS)stimuli are introduced for a comprehensive description.Moreover,the aggregated nanoparticles usually exhibit photothermal,photoacoustic,PET and enhanced MRI contrast,which is also described.In the end,we discuss about the potential applications and challenges for the future clinical translation.
基金
supported by the National Natural Science Foundation of China(No.81961138009)
the Young Elite Scientists Sponsorship Program by CAST(No.2017QNR001)
the Fundamental Research Funds for the Central Universities,111 Project(No.B18035)
RFBR and National Natural Science Foundation of China Collaboration Project(No.19-58-55001)。
