摘要
目的:探讨CA125阴性的上皮性卵巢癌患者的临床病理特征及生存状况。方法:基于2010年1月到2015年12月SEER数据库收录的卵巢癌患者信息,分析术前血清CA125阴性患者的临床病理特征及预后,并选取同期CA125阳性患者作为对照组。结果:CA125阴性卵巢癌患者多为非浆液性癌,年龄小于60岁,FIGO分期早,分化程度高。CA125阴性卵巢癌患者的总生存率为87.6%,显著高于阳性组的66.2%,差异有统计学意义(P<0.001)。多因素生存分析显示,CA125阴性是预后的独立相关因素,CA125阳性患者的死亡风险是CA125阴性患者的1.77倍。Kaplan-Meier生存曲线显示,不同病理类型中,CA125阴性组的总生存率均显著高于阳性组,差异有统计学意义(P<0.05)。结论:CA125阴性卵巢癌患者的预后好于CA125阳性患者。
Objective:To explore the relationship between clinicopathological features and survival status of patients with CA125 negative epithelial ovarian cancer.Methods:Based on the information of ovarian cancer patients collected in the SEER database from Jan.2010 to Dec.2015,the clinicopathological characteristics and prognosis of patients with preoperative serum CA125 negative were analyzed,and patients with CA125 positive in the same period were selected as the control group.Results:Most of the CA125 negative ovarian patients were non-serous cancers,younger than 60,early FIGO stage and high degree of differentiation.The overall survival rate of CA125 negative ovarian cancer patients was 87.6%,which was significantly higher than that of the positive group(66.2%),and the difference was statistically significant(P<0.001).Multivariate survival analysis showed that CA125 negative was an independent related factor of prognosis,and the risk of death in CA125 positive patients was 1.77 times higher than that in CA125 negative patients.The Kaplan-Meier survival curve showed that among different pathological types,the overall survival rate of the CA125 negative group was significantly higher than that of the positive group,and the difference was statistically significant.Conclusion:The prognosis of patients with CA125 negative ovarian cancer is better than that with CA125 positive patients.
作者
安民
郭建宾
段华
张颖
An Min;Guo Jianbin;Duan Hua(Department of Gynecological Minimally Invasive Center,Beijing Obstetrics and Gynecology Hospital,Capital Medical University,Beijing 100006)
出处
《现代妇产科进展》
CSCD
北大核心
2020年第8期576-579,共4页
Progress in Obstetrics and Gynecology
