摘要
程序性细胞死亡对于机体的生长发育及组织器官的稳态具有重要作用.坏死性凋亡是最近发现的一种可调控的程序性细胞死亡方式,其在形态学上具有坏死的特征.目前的研究表明,坏死性凋亡是由受体结合丝氨酸/苏氨酸蛋白激酶3(receptor-interacting serine/threonine-protein kinase 3,RIPK3)以及其底物混合谱系激酶结构域样蛋白(mixed lineage kinase domain-like protein,MLKL)共同介导.细胞的增殖和死亡在维持机体内环境稳态中发挥重要作用,大量研究表明坏死性凋亡的失调和人类疾病的发展密切相关,比如炎症性疾病、自身免疫性疾病、肿瘤以及退行性病变.在这篇综述中,将讨论坏死性凋亡的分子机制及其相关疾病的研究进展.
Programmed cell death is critical for maintenance cellular organisms homeostasis. Necroptosis is a recently identified mode of programmed cell death that morphologically similar to necrosis. Necroptosis is mediated by receptor-interacting serine/threonine-protein kinase 3(RIPK3) and its substrate mixed lineage kinase domain-like protein(MLKL). It has been shown that necroptosis is related to several human diseases, such as inflammatory diseases, autoimmune diseases, tumors and degenerative diseases. In this review, we will discuss the molecular mechanisms of necroptosis and its associated diseases.
作者
石珅男
覃夏
王红阳
蔡振宇
SHI Shen-Nan;QIN Xia;WANG Hong-Yang;CAI Zhen-Yu(Department of Cancer Institute,Fudan University Shanghai Cancer Center,Department of Oncology,Shanghai Medical College,Fudan University,Shanghai 200032,China;National Center for Liver Cancer,Shanghai 201805,China;The International Cooperation Laboratory on Signal Transduction,Eastern Hepatobiliary Surgery Hospital,Second Military Medical University,Shanghai 200438,China)
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
2020年第7期561-573,共13页
Progress In Biochemistry and Biophysics
基金
国家自然科学基金项目面上项目(81773075)
上海市科委国际合作项目(18410720600)资助~~。
