摘要
目的探讨正常肝组织、肝细胞癌Gd-EOB-DTPA(gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid,Gd-EOB-DTPA)增强前后低b值IVIM DWI双指数模型D~*、D、f值、单指数模型ADC值各参数特征,比较肿瘤组织与正常肝组织各参数的差别。方法 40例肝细胞癌且肝功能正常患者,肝细胞特异性对比剂Gd-EOB-DTPA增强扫描前及增强扫描后10min行低b值IVIM DWI检查(b值为0,20,40,60,80,100,200,400,600sec/mm^2),分析比较肿瘤组织增强前后、增强前肿瘤组织与正常肝组织IVIM DWI双指数模型D~*、D、f值,单指数模型ADC值(b值为0,200,400,600sec/mm^2)特征。增强前后正常肝组织、肿瘤组织不同参数的比较采用重复测量资料方差分析。肿瘤组织与正常肝组织各参数的比较采用单向方差分析。结果正常肝组织、肝细胞癌肿瘤组织Gd-EOB-DTPA增强前、增强后10min低b值IVIM DWI参数D~*、D、f值,单指数模型ADC值差异无统计学意义(P>0.05)。增强前后正常肝组织及肿瘤组织D值低于ADC值(P>0.05)。37例肝细胞癌肿瘤组织D值低于正常肝组织,3例肝细胞癌D值高于正常肝组织(P <0.05)。35例肝细胞癌肿瘤组织D~*值高于正常肝组织,5例肝细胞癌D~*值低于正常肝组织(P>0.05)。34例肝细胞癌肿瘤组织f值高于正常肝组织,6例肿瘤组织f值低于正常肝组织(P>0.05)。结论肝脏Gd-EOB-DTPA增强前后低b值IVIM DWI各参数差异无统计学意义,为优化检查方案、节省检查时间,可于Gd-EOB-DTPA增强后行肝脏低b值IVIM DWI检查。肝脏低b值IVIM DWI各参数有助于进一步评价肝细胞癌。
Objective To evaluate the D~*,D,f features of normal liver and HCC(hepatocellular carcinoma,HCC) with low b values during before and after enhancement Gd-EOB-DTPA(gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid,Gd-EOB-DTPA),and to compare the differences of the normal liver and the tumor tissue.Methods 40 patients with HCC were included in this study between December 2011 and July 2013,all the patients with normal liver function,and all the patients underwent IVIM DWI(b value was 0,20,40,60,80,100,200,400,600sec/mm^2)examination before and 10 min after enhancement with Gd-EOB-DTPA,comparing the D~*,D,f,ADC(b value was 0,200,400,600sec/mm^2) features of normal liver and HCC before and after enhancement with Gd-EOB-DTPA.Analysis of variance repeated measures were performed in analyzing the differences of the parameters of different tissues before and after enhancement with Gd-EOB-DTPA.One-way analysis of variance was performed in analyzing the differences of the parameters between the normal liver tissue and tumor tissue.Results Before and 10min after enhancement with Gd-EOB-DTPA,the differences of ADC,D,D~*,f values between the normal liver tissues and tumor tissues were not significant (P>0.05).The D values of the normal liver tissues and tumor tissues were lower than the ADC values of the same tissues(P>0.05).The D values of the tumor tissues were lower than those of the normal liver tissues in 37 patients,the D values of the tumor tissues were higher than those of the normal liver tissues in 3 patients(P<0.05).The D~* values of the tumor tissues were higher than those of the normal liver tissues in 35 patients,the D values of the tumor tissues were lower than those of the normal liver tissues in 5 patients(P>0.05).The f values of the tumor tissues were higher than those of the normal liver tissues in 34 patients,the D values of the tumor tissues were lower than those of the normal liver tissues in 6 patients(P>0.05).Conclusion There were no significant differences of the parameter features of IVIM DWI with low b value between before and 10min after enhancement with Gd-EOB-DTPA,for the optimization of scanning proposal,and for saving the scanning time,IVIM DWI scan can be performed after 10min enhancement with Gd-EOB-DTPA.The parameter features of low b value IVIM DWI is useful for evaluating HCC.
作者
苏瑾
李景雷
赵心竹
刘于宝
SU Jin;LI Jing-lei;ZHAO Xin-zhu(Department of Radiology,Shenzhen Hospital,Southern Medical University,Shenzhen 518101,Guangdong Province,China)
出处
《中国CT和MRI杂志》
2020年第9期110-113,共4页
Chinese Journal of CT and MRI
关键词
肝细胞癌
钆乙氧基苯甲基二乙烯五胺乙酸
磁共振成像
体素内不相干运动
扩散加权成像
Hepatocellular Carcinoma
Gadolinium Ethoxybenzyl Diethylenetriamine Pentaacetic Acid
Magnetic Resonance Imaging
Intravoxel Incoherent Motion
Diffusion-Weight Imaging
