摘要
目的:探讨非酒精性脂肪肝(NAFLD)人群中维生素D水平与颈动脉斑块之间的关系。方法:选取2017年1月-2018年4月在笔者所在医院确诊为非酒精性脂肪肝的患者296例。分别记录患者一般资料,检测甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、极低密度脂蛋白胆固醇(VLDL-C)、胱抑素C(Cys C)水平、25-羟维生素D(25-OH-VD)水平,测定各组患者血清组织蛋白酶S(cathepsin S,Cat S)、白介素-1β(IL-1β)、高迁移率族蛋白1(HMGB1)、血清特异性丝氨酸蛋白酶抑制因子(Vaspin)水平。测量颈动脉内膜中层厚度(IMT)及Crouse积分,根据彩超检查结果分为颈动脉斑块组64例,对照组202例,正常组30例,分析维生素D与颈动脉斑块的相关性及其危险因素。结果:颈动脉斑块组Cys C水平均低于对照组及正常组,IL-1β、HMGB1、Vaspin、Cat S水平均高于对照组及正常组,差异均有统计学意义(P<0.05);颈动脉斑块组Crouse积分均高于对照组及正常组,维生素D水平均低于对照组及正常组,差异均有统计学意义(P<0.05);Pearson相关系数分析显示,颈动脉板块组血清维生素D含量与IMT、Crose积分均存在线性负相关关系(r=-0.452、-0.602,P=0.000);多因素回归分析校正混杂因素后发现,维生素D缺乏是颈动脉粥样硬化的独立危险因素,其他因素如低密度脂蛋白胆固醇过高、甘油三酯过高、年龄增大、吸烟较多等也与颈动脉斑块形成有密切关系,差异均有统计学意义(P<0.05)。结论:NAFLD患者维生素D缺乏与颈动脉斑块形成的风险相关。
Objective:To investigate the relationship between vitamin D level and carotid plaque in NAFLD population.Method:A total of 296 patients with non-alcoholic fatty liver disease were selected from January 2017 to April 2018 in the author’s hospital.The general data respectively,and detection of triglyceride(TG),total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),low density lipoprotein cholesterol(VLDL-c),urinary inhibition C(Cys C)levels,25-hydroxy vitamin D(25-OH-VD)level,measurement of carotid intima-media thickness(IMT)and Crouse integral of patients were measured,the Serum cathepsin S(Cat S),interleukin-1β(IL-1β),high mobility group protein 1(HMGB1),and serum specific serine protease inhibitor(Vaspin)levels were measured.According to the results of color ultrasound examination,the patients were divided into 64 cases of the carotid plaque group,202 cases of the control group and 30 cases of the normal group.The correlation between vitamin D and carotid plaque and its risk factors were analyzed.Result:The serum levels of Cys C in the carotid plaque group were lower than those in the control group and the normal group,and the levels of IL-1β,HMGB1,Vaspin and Cat S were higher than those in the control group and the normal group,the differences were statistically significant(P<0.05).The Crouse scores in the carotid plaque group were higher than those in the control group and the normal group,and the vitamin D levels were lower than those in the control group and the normal group,the differences were statistically significant(P<0.05).Pearson correlation coefficient analysis showed that there was a linear negative correlation between serum vitamin D content and IMT and Crose integrals in the carotid artery group(r=-0.452,-0.602,P=0.000).Multiple factors regression analysis after adjustment for confounding factors found that,vitamin D deficiency was independent risk factors for carotid atherosclerosis,other factors such as high LDL cholesterol,high triglycerides,older age,and smoking were also associated with carotid plaque formation,the differences were statistically significant(P<0.05).Conclusion:Vitamin D deficiency in patients with NAFLD is associated with the risk of carotid plaque formation.
作者
林仕忠
陈武
温玉玺
韩美兰
翁华妹
LIN Shizhong;CHEN Wu;WEN Yuxi;HAN Meilan;WENG Huamei(Fuqing Hospital,Fuqing 350300,China;不详)
出处
《中外医学研究》
2020年第18期163-167,共5页
CHINESE AND FOREIGN MEDICAL RESEARCH
