摘要
目的:研究子痫前期患者应用肠溶阿司匹林联合低分子肝素(LMWH)对孕早期血清学指标和超声血流监测参数的影响。方法:将96例重度子痫前期患者按照入院顺序均分为对照组和研究组。对照组给予常规治疗,研究组在此基础上给予肠溶阿司匹林和LMWH联合治疗。比较两组血清学指标和超声胎盘血流监测参数,并分析安全性。结果:治疗后,研究组sFlt-1水平低于对照组,PLGF和VEGF水平均高于对照组,差异均有统计学意义(P<0.05);研究组超声胎盘血流监测参数(PI、RI、S/D)均低于对照组,差异均有统计学意义(P<0.05);研究组不良反应发生率(8.33%)显著低于对照组(27.08%),差异有统计学意义(P<0.05)。结论:采用肠溶阿司匹林联合LMWH治疗重度子痫前期患者可有效改善孕早期血清学指标和超声胎盘血流监测参数,治疗安全性较高。
Objective:To study the effect of combined therapy of Aspirin Enteric-coated and Low Molecular Weight Heparin (LMWH) on serological indicators and ultrasonic blood flow monitoring parameters in early pregnancy in patients with preeclampsia.Method:A total of 96 patients with severe preeclampsia were divided into the control group and the study group according to the order of admission.The control group was given conventional treatment,and on this basis,the study group was given Aspirin Enteric-coated combined with LMWH treatment.The serological indicators and ultrasonic blood flow monitoring parameters were compared between the two groups,and safety was analyzed.Result:After treatment,the level of sFlt-1 in the study groups was lower than that of the control group,and the levels of PLGF and VEGF were higher than those of the control group,and the differences were statistically significant (P<0.05).The ultrasonic blood flow monitoring parameters (PI,RI and S/D) in the study group were lower than those of the control group,and the differences were statistically significant (P<0.05).The incidence of adverse reactions in the study group (8.33%) was significantly lower than that of the control group (27.08%),and the difference was statistically significant (P<0.05).Conclusion:Aspirin Enteric-coated combined with LMWH in the treatment of patients with severe preeclampsia can effectively improve serological indicators and ultrasonic blood flow monitoring parameters in early pregnancy,and the treatment safety is higher.
作者
王健琴
WANG Jianqin(Wuyishan Municipal Hospital,Wuyishan 354300,China)
出处
《中外医学研究》
2020年第21期23-24,共2页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
子痫前期
肠溶阿司匹林
低分子肝素
血清学指标
超声血流监测
Preeclampsia
Aspirin Enteric-coated
Low Molecular Weight Heparin
Serological indicators
Ultrasonic blood flow monitoring
