摘要
目的:探讨注射用亚胺培南西司他丁与乌司他丁联合治疗重度烧伤的临床效果及安全性。方法:选取笔者所在医院2014年1月-2017年12月100例重度烧伤患者作为研究对象,按照随机数字表法将其分为联合组(n=50)与对照组(n=50)。对照组给予常规治疗,联合组在对照组基础上给予注射用亚胺培南西司他丁与乌司他丁联合治疗。比较两组治疗效果及安全性。结果:联合组治疗总有效率为88.00%,高于对照组68.00%,差异有统计学意义(P<0.05)。治疗后两组血清IL-6、IL-8、IL-10水平均较治疗前显著降低,且联合组降低程度显著优于对照组,差异有统计学意义(P<0.05)。联合组不良反应发生率为2.00%,显著低于对照组的14.00%,差异有统计学意义(P<0.05)。结论:注射用亚胺培南西司他丁与乌司他丁联合治疗重度烧伤的效果显著,能够提高临床效果,减轻炎症侵袭,提高用药安全性,值得临床中应用。
Objective:To investigate the clinical efficacy and safety of Imipenem and Cilastatin Sodium for Injection combined with Ulinastatin in the treatment of severe burns.Method:A total of 100 patients with severe burns from January 2014 to December 2017 in our hospital were selected as the research objects and divided into the combined group(n=50)and the control group(n=50)according to the random number table method.The control group received routine treatment.The combined group received Imipenem and Cilastatin Sodium for Injection combined with Ulinastatin treatment on the basis of the control group.The efficacy and safety of the two groups were compared.Result:The total effective rate of the combined group was 88.00%,which was higher than 68.00%of the control group,the difference was statistically significant(P<0.05).After treatment,the levels of serum IL-6,IL-8 and IL-10 in both groups were significantly lower than those before treatment,and the reduction degree of the combined group was significantly better than that of the control group,the differences were statistically significant(P<0.05).The incidence of adverse reactions in the combined group was 2.00%,which was significantly lower than 14.00%in the control group,the difference was statistically significant(P<0.05).Conclusion:Imipenem and Cilastatin Sodium for Injection combined with Ulinastatin has a significant effect in the treatment of severe burns,which can improve the clinical efficacy,reduce inflammatory invasion,and improve the safety of medication.It is worthy of clinical application.
作者
谢晓勇
XIE Xiaoyong(Dongguan Kanghua Hospital,Dongguan 523000,China)
出处
《中外医学研究》
2020年第21期20-22,共3页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
重度烧伤
注射用亚胺培南西司他丁
乌司他丁
炎症因子
安全性
Severe burns
Imipenem and Cilastatin Sodium for Injection
Ulinastatin
Inflammatory factors
Safety
