摘要
目的:研究氯呲格雷联合尿激酶治疗急性心肌梗死(AMI)的效果及对其炎症水平的影响。方法:选取2018年5月-2019年8月于笔者所在医院就诊的AMI患者83例,按照随机数字表法分为对照组(41例)和研究组(42例)。对照组行尿激酶联合阿司匹林治疗,研究组行尿激酶联合氯吡格雷治疗。观察两组临床疗效、凝血功能、炎症水平、不良反应发生率。结果:研究组临床治疗总有效率(90.48%)高于对照组(80.49%),差异有统计学意义(P<0.05)。治疗后研究组血小板聚集率(PAG)低于对照组,活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)均长于对照组,差异均有统计学意义(P<0.05);治疗后研究组C反应蛋白(CRP)、肌酸激酶同工酶MB亚型(CK-MB)、肌钙蛋白T(TnT)均低于对照组,差异均有统计学意义(P<0.05);研究组不良反应发生率为9.52%,对照组为14.63%,差异无统计学意义(P>0.05)。结论:氯呲格雷联合尿激酶治疗AMI可显著提高临床疗效,纠正凝血功能紊乱,抑制炎症反应,且安全性较高,可临床推广。
Objective:To study the effect of Clopidogrel combined with Urokinase on acute myocardial infarction (AMI) and its inflammatory level.Method:A total of 83 patients with AMI who were treated in our hospital from May 2018 to August 2019 were divided into the control group (41 cases) and the study group (42 cases) according to the random number table method.The control group was treated with Urokinase and Aspirin,and the study group was treated with Urokinase and Clopidogrel.The clinical effective rate,coagulation function,inflammation level and the incidence of adverse reactions were observed.Result:The clinical effective rate in the study group was 90.48%,significantly higher than 80.49% in the control group,the difference was statistically significant (P<0.05).After treatment,The platelet aggregation rate (PAG) in the study group was lower than that in the control group,the activated partial thromboplastin time (APTT) and prothrombin time (PT) were longer than those in the control group,the differences were statistically significant (P<0.05).After treatment,the C-reactive protein (CRP),creatine kinase isoenzyme MB subtype (CK-MB) and troponin T (TnT) in the study group were lower than those in the control group,the differences were statistically significant (P<0.05).The adverse reactions were 9.52% in the study group and 14.63% in the control group,there was no significant difference (P>0.05).Conclusion:Clopidogrel combined with Urokinase in treatment of AMI can significantly improve the clinical efficacy,correct the coagulation disorder,inhibit the inflammatory response,and has high safety,which can be widely used in clinical practice.
作者
林康华
黄飞龙
LIN Kanghua;HUANG Feilong(Wuchuan People’s Hospital,Wuchuan 524500,China;不详)
出处
《中外医学研究》
2020年第16期13-15,共3页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
急性心肌梗死
氯呲格雷
尿激酶
炎症反应
Acute myocardial infarction
Clopidogrel
Urokinase
Inflammatory response
