摘要
目的:探讨布地奈德/福莫特罗吸入联合低流量吸氧对慢性阻塞性肺疾病(COPD)稳定期伴呼吸衰竭患者临床疗效。方法:选取笔者所在医院2019年1-12月收治的130例COPD稳定期伴呼吸衰竭患者作为研究对象,按照随机数字表法将其分为观察组(65例)和对照组(65例),两组均进行常规治疗,观察组在此基础上持续低流量供氧,加用布地奈德/福莫特罗治疗。对比两组动脉血气分析指标、肺功能、运动功能指标和临床疗效。结果:治疗后两组PaO2值均高于治疗前,PaCO2值均低于治疗前,且观察组PaO2、PaCO2值均优于对照组,差异均有统计学意义(P<0.05);治疗后两组FEV1%、FEV1/FVC值高于治疗前,且观察组FEV1%、FEV1/FVC值均高于对照组,差异均有统计学意义(P<0.05);治疗后两组6MWD值均高于治疗前,mMRC评分均低于治疗前,且观察组6MWD、mMRC评分均优于对照组,差异均有统计学意义(P<0.05);观察组临床总有效率优于对照组,差异有统计学意义(P<0.05)。结论:布地奈德/福莫特罗吸入联合低流量吸氧对COPD稳定期伴呼吸衰竭患者有显著效果,值得在临床推广使用。
Objective:To explore the effect of Budesonide/Formoterol combined with low flow oxygen inhalation on the clinical efficacy of COPD patients with respiratory failure in stable stage.Method:A total of 130 patients from January to December 2019 in our hospital were selected,and were divided into the observation group (65 cases) and the control group (65 cases) according to the method of random number table.The two groups were treated with routine treatment,the observation group continued to supply oxygen with low flow on the basis,plus Budesonide/Formoterol.The arterial blood gas analysis index,pulmonary function,motor function index and clinical effect of the two groups were compared.Result:After treatment,the PaO2 values in the two groups were higher than those before treatment,and the PaCO2 in the two groups were lower than those before treatment,and the PaO2 and PaCO2 values in the observation group were better than those in the control group,the differences were statistically significant (P<0.05).After treatment,the FEV1%,FEV1/FVC values in the two groups were higher than those before treatment,and the FEV1%,FEV1/FVC values in the observation group were higher than those in the control group,the differences were statistically significant (P<0.05).After treatment,the 6MWD values in the two groups were higher than those before treatment,the mMRC scores in the two groups were lower than those before treatment,and the 6MWD,mMRC score in the observation group were better than those in the control group,the differences were statistically significant (P<0.05).The total clinical effective rate in the observation group was better than that in the control group,the difference was statistically significant (P<0.05).Conclusion:Budesonide/Formoterol combined with low flow oxygen inhalation has a significant effect on patients with respiratory failure in the stable period of COPD,which is worthy of clinical application.
作者
何玉萍
刘艳秀
麦湛文
HE Yuping;LIU Yanxiu;MAI Zhanwen(Yunfu People’s Hospital,Yunfu 527300,China;不详)
出处
《中外医学研究》
2020年第16期6-8,共3页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
布地奈德/福莫特罗
慢性阻塞性肺疾病
稳定期
呼吸衰竭
肺功能
Budesonide/Formoterol
Chronic obstructive pulmonary disease
Stable period
Respiratory failure
Pulmonary function
