摘要
目的:探究软组织肉瘤(STS)患者中医体质类型的分布规律,进一步探究体质类型差异对此类患者化学治疗(简称化疗)后发生骨髓抑制的影响。方法:收集北京大学肿瘤医院就诊的STS患者的临床病例,填写调查表并记录患者治疗期间发生骨髓抑制的情况,对此进行归纳整理、统计分析。结果:共收集符合纳入病例81份,STS患者以气虚质最为常见,阴虚质及阳虚质次之。其他体质类型少见;局限期组与晚期组两组各体质类型分布差异有统计学意义(P=0.007)。局限期患者的气虚质分布概率高于晚期患者(P=0.012),而晚期患者阴虚质分布概率显著高于局限期患者(P=0.006)。不同体质类型患者化疗后骨髓抑制发生率存在差异。阳虚质患者相比气虚质(P=0.013)及阴虚质(P=0.031)更容易出现重度骨髓抑制。结论:STS患者以气虚质、阳虚质及阴虚质为多见,阳虚质患者更需警惕化疗后出现重度骨髓抑制。
Objective:To explore the distribution regularity of traditional Chinese medical constitution types in patients with soft tissue sarcoma(STS),and to further explore the influence of constitution type differences on bone marrow suppression after chemotherapy in such patients.Methods:Collect the clinical cases of STS patients in Peking University Cancer Hospital&Institute,fill in the questionnaire and record the occurrence of bone marrow depression during the treatment,and summarize and analyze the data.Results:A total of 81 eligible cases were collected.The results showed that qi deficiency was the most common type of STS patients,followed by yin deficiency and yang deficiency.Other types of constitution are rare;there is significant difference in the distribution of constitution types between the limited stage group and the advanced stage group(P=0.007).The distribution probability of qi deficiency in patients with limited stage was higher than that in patients with advanced stage(P=0.012),while the distribution probability of yin deficiency in patients with advanced stage was significantly higher than that in patients with limited stage(P=0.006).The incidence of bone marrow suppression after chemotherapy was different in patients with different constitutional types.Compared with qi deficiency(P=0.013)and yin deficiency(P=0.031),patients with yang deficiency were more likely to have severe bone marrow depression.Conclusion:qi deficiency,yang deficiency and yin deficiency are common in STS patients.Patients with yang deficiency need to be more alert to severe bone marrow suppression after chemotherapy.
作者
孟博
孙红
MENG Bo;SUN Hong(Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education),Department of Integration of Traditional Chinese Medicine and Western Medicine&Geriatric Oncology,Peking University Cancer Hospital&Institute,Beijing 100142,China)
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2020年第6期3269-3272,共4页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
北京中医药科技发展资金项目(No.JJ2018-40)。
关键词
中医体质
软组织肉瘤
骨髓抑制
化学治疗
Constitution of traditional Chinese medicine
Soft tissue sarcoma
Bone marrow suppression
Chemotherapy
