摘要
目的系统性评价收缩压和舒张压值对脑白质病变进展的影响。方法本文从美国国立医学图书馆生物医学信息检索系统(PubMed)和Cochrane Library数据库中以“white matter”“Leukoencephalopathy”“leukoaraiosis”“blood pressure”“hypertension”作为标题关键词,检索时限为1981年至2019年8月,分别搜索出174和101篇文章,然后由2名研究者独立筛选、评价纳入的文献,采用RevMan 5.3软件进行meta分析。结果最终共纳入12篇密切相关的文献进行研究。Meta分析结果显示收缩压与舒张压值的升高均对脑白质病变的进展具有着促进作用(分别为OR=2.90,95%CI 2.86~2.95;OR=3.13,95%CI 3.03~3.23),尤以舒张压为甚。结论收缩压与舒张压值的升高均可促进脑白质病变的进展,但与舒张压的关系更密切,因此希望能有更多的研究者关注舒张压的变化,更希望能够明确控制舒张压对延缓脑白质病变进展有益的血压值范围和控制策略,尤其是70岁以下的患者。
Objective To systematically evaluate the effect of systolic and diastolic blood pressure on the progression of White matter lesions.Methods The title term“white matter”“Leukoencephalopathy”“leukoaraiosis”“blood pressure”“hypertension”in PubMed and Cochrane Library were searched for 174 AND 101 articles respectively from 1981 to August 2019.Then two researchers independently screened AND evaluated the included literatures,AND meta-analysis was performed using RevMan 5.3 software.Results Finally,a total of 11 closely related studys were included for research.The results of meta-analysis showed that the increase of systolic blood pressure and diastolic blood pressure could promote the progression of white matter lesions(Respectively OR=2.90,95%CI 2.86~2.95;OR=3.13,95%CI 3.03~3.23),especially in diastolic blood pressure.Conclusion The increase of systolic blood pressure and diastolic blood pressure can promote the progress of white matter lesions,but it is more closely related to diastolic blood pressure.Therefore,more researchers are expected to pay attention to the change of diastolic blood pressure,and more importantly,to identify the range of blood pressure and control strategies that control diastolic blood pressure is beneficial to delay the progress of white matter lesions,especially for patients under 70 years old.
作者
张栋
何明利
葛建
刘雨朦
金晶
唐逸
ZHANG Dong;HE Mingli;GE Jian(Department of Neurology,Xuzhou Medical University Affiliated Hospital of Lianyungang,Lianyungang 222000,China)
出处
《中风与神经疾病杂志》
CAS
2020年第7期600-606,共7页
Journal of Apoplexy and Nervous Diseases
基金
国家自然科学基金项目(No.81970348)。
关键词
血压
脑白质病变
高血压
META分析
Blood pressure
White matter lesions
Hypertension
Meta-analys
