摘要
目的探究原发性结肠癌患者白细胞变化规律。方法将2015年1月至2019年8月在华润武钢总医院肿瘤科住院部或门诊首次诊断为原发性结肠癌患者132例纳入研究,对结肠癌组中每例患者采用严格的对照匹配,即以未患结肠癌的健康人为对照。得结肠癌组132例,正常对照组132例。收集结肠癌组及正常对照组静脉血血细胞化验单,记录白细胞:中性粒细胞、淋巴细胞、单核细胞、嗜酸性粒细胞、嗜碱性粒细胞绝对值。比较结肠癌组与正常对照组白细胞水平。同时应用相关分析分析结肠癌组患者中性粒细胞、嗜酸性粒细胞等白细胞的相关性变化。结果与正常对照组相比,结肠癌组中性粒细胞、淋巴细胞水平明显升高(P<0.01);嗜酸性粒细胞水平升高(P<0.05);采用Pearson分析,发现结肠癌组中性粒细胞改变与淋巴细胞、嗜酸性粒细胞改变存在一定相关性,且为正相关(P<0.01)。结论与正常人群相比,原发性结肠癌患者中性粒细胞、淋巴细胞、嗜酸性粒细胞升高明显,同时三者升高具有一定的正相关性。
Objective To investigate the white blood cell level changeregulationin primary colon cancer patients.Methods From January 2015 to August 2019,132 cases diagnosed as primary colon cancer complying with the inclusion criteria in Huarun Wugang General HospitalOncology Department or Outpatient Department were selected as the research subjects.At the same time 132 common people complying with the relative inclusion criteria were selected as the common control group.The blood checking reports of each subject’s vessel blood were collected,the absolute values of Neutrophile Granulocyte,Lymphocyte,Monocyte,Eosinophile Granulocyte,Basophile Granulocyte were recorded and analyzed by SPSS 19.0 statistical software with T test and Bivariate correlation to compare the WBC difference between the primary colon cancer group and common control group.Results Compared with the common control group,the Neutrophile Granulocyte andLymphocyte levels of primary colon cancer group increased significantly,P<0.01.The Eosinophile Granulocyte level increased,P<0.05.Applying the Pearson analysis,the positive correlation between Neutrophile Granulocyte,Lymphocyte and Eosinophile Granulocyte levels in primary colon cancer patients was found,P<0.01.Conclusion Compared with the common people,the Neutrophile Granulocyte,Lymphocyte and Eosinophile Granulocyte levels in primary colon cancer patients are higher,and there is a with positive correlation between the three WBC indexes.
作者
罗毅
王俊
郭文浩
邓飞
LUO Yi;WANG Jun;GUO Wen-hao;DENG Fei(Interventional Pain Vascular Surgery Department,Huazhong Technology University Xiehe East and West Lake Hospital,Hubei Wuhan 430040;Oncology Department Huarun Wugang General Hospital,Hubei Wuhan 430080;Oncology Department Sanxia University the Second People’s Hospital,Hubei Yichang City the Second People's Hospital,Hubei Yichang 443000,Chan)
出处
《昆明医科大学学报》
CAS
2020年第7期125-129,共5页
Journal of Kunming Medical University
基金
湖北省自然科学基金资助项目(2017CFB455)。
