摘要
急性和慢性肾脏疾病都会发生缺氧,即细胞和组织缺氧。缺氧诱导因子(HIF)是缺氧状态下基因表达的“主”转录因子。研究表明,HIF通过调节HIF的靶基因在肾脏损伤和修复中发挥重要作用。然而关于HIF在肾脏损伤和修复中的病理作用还存在争议,基于此,本文主要就HIF在肾脏中的分布及检测、HIF的靶基因及其对肾脏内分泌功能的影响、HIF在急性肾损伤(AKI)中的信号机制及在肾脏修复中的作用作一综述,旨在为阐明HIF在肾脏损伤和修复中的病理作用提供帮助。
Both acute and chronic kidney disease can cause hypoxia,thatis,hypoxia in cells and tissues.Hypoxia-inducible factor(HIF)is the"master"transcription factor for gene expression under hypoxia.Studies have shown that HIF plays an important role in kidney injury and repair by regulating the target genes of HIF.However,there is still controversy about the pathological role of HIF in kidney injury and repair.Based on this,this article mainly focuses on the distribution and detection of HIF in the kidney,the target genes of HIF and their effects on renal endocrine function,and HIF in acute kidney injury(AKI)is a review of the signaling mechanism and its role in kidney repair,aiming to help elucidate the pathological role of HIF in kidney injury and repair.
作者
王宁
巴应贵
WANG Ning;BA Ying-gui(Qinghai University,Xining 810000,Qinghai,China)
出处
《医学信息》
2020年第14期47-50,共4页
Journal of Medical Information
关键词
缺氧
低氧诱导因子
肾损伤
肾脏修复
Hypoxia
Hypoxia-induciblefactor
Kidneyinjury
Kidney repair
