摘要
目的:本研究旨在评估益生菌对尿毒症腹膜透析患者的营养不良状态和腹膜炎发病率的影响。方法:116例腹膜透析患者随机、平均分为实验组(n=58)和对照组(n=58)。实验组每天服用1×109 CFU的益生菌,持续2个月,对照组同期服用安慰剂。记录所有受试者的基线和干预期结束时的生化指标、体格数据(包括体重指数、上臂围、左小腿围、肱三头肌皮褶厚度、脂肪质量)及腹膜炎发病率,直到半年的随访结束。结果:与对照组比较,经过2个月的益生菌治疗后,实验组血浆超敏C-反应蛋白(hsCRP)的水平降低(8.25±3.22 vs 5.04±2.81,P<0.01),而血浆白蛋白水平(38.96±6.78 vs 42.78±6.97,P<0.01)、上臂围(23.78±2.70 vs 25.26±3.21,P<0.01)和肱三头肌皮褶厚度(10.09±4.83 vs 13.50±5.29,P<0.01)显著升高。随访结束时实验组的腹膜炎发病率也低于对照组(P<0.05)。结论:益生菌可以显著降低腹膜透析患者血中hsCRP的浓度、提高血浆白蛋白水平、增加上臂围和肱三头肌皮褶厚度。益生菌可以降低腹膜透析患者的腹膜炎发病率。
Objective:The purpose of this study was to evaluate the clinical efficacy of probiotics on state of malnutrition and peritonitis episodes in peritoneal dialysis(PD)patients.Methods:A total of 116 PD patients were randomly divided into an intervention group(n=58)and a control group(n=58).The intervention group received a daily dose of probiotics(1×109 CFU/d)for two months,while the control group did not receive probiotics for the same duration.Biochemical indicators and physical measurements including body mass index(BMI),upper arm circumference(AC),left calf circumference(LCC),triceps skinfold thickness(TSF)and fat mass were measured before and two months after the intervention.The peritonitis episodes were also recorded after 6 months of follow-up.Results:Among patients receiving probiotics,the levels of hsCRP decreased after two months of treatment(8.25±3.22 vs 5.04±2.81,P<0.01),while the levels of serum albumin(38.96±6.78 vs 42.78±6.97,P<0.01),AC(23.78±2.70 vs 25.26±3.21,P<0.01)and TSF(10.09±4.83 vs 13.50±5.29,P<0.01)increased significantly.The peritonitis rate of the probiotic group was lower than that of the control group after 6 months(P<0.05).Conclusion:Probiotics could significantly decrease the serum levels of hsCRP and increase the levels of serum albumin,AC and TSF in PD patients.As a result,the cumulative incidence of peritonitis was reduced after probiotic supplementation in PD patients.
作者
潘阳彬
林贝多
戴宾宾
杨丽燕
林恩琴
PAN Yangbin;LIN Beiduo;DAI Binbin(Department of Nephrology,Shanghai Pudong Hospital,Shanghai,201399;Department of Nephrology,the First Affiliated Hospi)
出处
《中国中西医结合肾病杂志》
2020年第6期493-496,共4页
Chinese Journal of Integrated Traditional and Western Nephrology
关键词
尿毒症
益生菌
腹膜透析
营养不良
腹膜炎
UremiaProbiotic
Peritoneal dialysis
Malnutrition
Peritonitis
