摘要
前体脂肪细胞分化过程即脂肪生成过程,在此过程中大量转录因子、非编码RNA及信号通路都发挥着重要的作用。文章综述了前体脂肪细胞分化过程中,成脂基因如C/EBPα和PPARγ等对前体脂肪细胞分化的调控;非编码RNA如长链非编码RNA(lncRNA)、小RNA(microRNA)、环状RNA(circRNA)对脂肪沉积、组织发育以及能量代谢等的调控过程;信号通路如Wnt/β-catenin信号通路、促分裂原活化蛋白激酶(MAPK)信号通路、Hedgehog信号通路对脂肪细胞分化的抑制作用;还有一些酶、抑制剂等对前体脂肪细胞诱导分化的调节作用,以期为厘清前体脂肪细胞诱导及分化机制提供参考。
The differentiation of preadipocytes is the process of adipogenesis, in which a large number of transcription factors, non-coding RNA and signaling pathways all play an important role. This article reviewed the regulation of lipogenic genes(C/EBP alpha and PPAR) on the differentiation of preadipocytes, the regulation of non-coding RNA(lncRNA, microRNA and circRNA) on fat deposition, tissue development and energy metabolism, the inhibitory effect of signaling pathways(Wnt/beta-catenin signaling pathway, MAPK signaling pathway and Hedgehog signaling pathway) on adipocyte differentiation, and the regulation of some enzymes and inhibitors on the differentiation of preadipocytes during the differentiation of preadipocytes. This study provided a reference for understanding the mechanism of preadipocyte induction and differentiation.
作者
敖慧娟
王家敏
乔自林
阿依木古丽·阿不都热依木
杨琨
杨迪
AO Huijuan;WANG Jiamin;QIAO Zilin;AYIMUGULI·Abuduoreyimu;YANG Kun;YANG Di(Biomedical Research Center/Gansu Tech Innovation Center of Animal Cell,Northwest Minzu University,Lanzhou 730030,China;College of Life Science and Engineering,Northwest Minzu University,Lanzhou 730030,China;Biomedical Research Center/Key Laboratory of Biotechnology and Bioengineering of State Ethnic Affairs Commission,Northwest Minzu University,Lanzhou 730030,China;Experiment Teaching Department,Northwest Minzu University,Lanzhou 730030,China)
出处
《黑龙江畜牧兽医》
CAS
北大核心
2020年第13期36-39,共4页
Heilongjiang Animal Science And veterinary Medicine
基金
中央高校基本科研业务费专项“西北民族大学动物细胞培养与代谢工程创新团队项目”(31920190004)
西北民族大学“双一流”和特色发展引导专项“生物工程特色学科”(10018703,1001070204)
家养动物种质资源平台运行服务项目(XBMU-2017-BC-07)。
关键词
前体脂肪细胞
成脂基因
非编码RNA
信号通路
分化
preadipocytes
lipogenic genes
non-coding RNA
signaling pathways
differentiation
