摘要
目的探讨盐酸安罗替尼治疗晚期妇科肿瘤的疗效及安全性。方法收集2018年7月至2019年6月我院肿瘤一科确诊的晚期妇科肿瘤患者22例,给予患者口服盐酸安罗替尼胶囊12 mg/(次·d),连续服药2周,停药1周,3周为1个治疗周期,每6周对疗效进行评估1次,观察分析患者的临床疗效、无进展生存期(PFS)及不良反应情况。结果14例卵巢癌患者的疾病控制率(DCR),客观缓解率(ORR)分别为85.71%、57.14%;4例宫颈癌的DCR及ORR分别为100.00%、50.00%;4例子宫内膜癌的DCR及ORR分别为75.00%、50.00%。此外,14例晚期卵巢癌患者的中位PFS为10.80个月,4例宫颈癌的中位PFS为12.50个月,4例子宫内膜癌的中位PFS为15.50个月。22例患者未出现4级不良反应发生,耐受性良好。结论盐酸安罗替尼治疗晚期妇科肿瘤,可有效控制病情发展,延长患者生存期,并且具有较好的安全性。
Objective To observe the efficacy and safety of anlotinib in the treatment of advanced gynecological cancer.Methods A total of twentytwo patients with advanced gynecological tumors diagnosed in the first department of tumor,liaoning provincial people’s hospital from July 2018 to June 2019 were given anlotinib for treatment.Patients were given anlotinib capsules 12 mg/(time·d)for 2 weeks,1 week of with drawal,and 1 treatment cycle for 3 weeks.The efficacy was evaluated every 6 weeks,and the clinical efficacy,progress-free survival(PFS)and adverse reactions were observed and analyzed.Results The disease control rate(DCR)and objective response rate(ORR)of 14 patients with ovarian cancer were 85.71%and 57.14%,respectively.The DCR and ORR of 4 cases of cervical cancer were 100.00%and 50.00%respectively.The DCR and ORR of 4 cases of intrauterine carcinoma were 75.00%and 50%respectively.In addition,the median PFS was 10.80 months in 14 patients with advanced ovarian cancer,12.50 months in 4 patients with cervical cancer,and 15.50 months in 4 patients with intrauterine cancer.No grade 4 serious adverse reactions occurred in 22 patients,and they were well tolerated.Conclusion The treatment of late gynecologic cancers with anlotinib can effectively control the disease progression and prolong the survival of patients with good safety.
作者
郑爽
张志强
王晓舟
王梓瑛
马怡
刘爽
韩彧佳
赫丽杰
ZHENG Shuang;ZHANG Zhiqiang;WANG Xiaozhou;WANG Ziying;MA Yi;LIU Shuang;HAN Yujia;HE Lijie(No.1 Department of Medical Oncology,Liaoning Provincial People′s Hospital(the People's Hospital of China Medical University),Shenyang 110016,China)
出处
《中国医药指南》
2020年第22期45-46,51,共3页
Guide of China Medicine
基金
2018年沈阳市中青年科技创新人才支持计划项目(RC180334)。
关键词
妇科肿瘤
盐酸安罗替尼
疗效
安全性
Gynecological cancer
Anrotinib hydrochloride
Efficacy
Safety
