摘要
目的:探究用吗替麦考酚酯联合小剂量泼尼松治疗微小病变性肾病(minimal change nephr opathy,MCN)的临床效果。方法:将近年来高州市高州人民医院肾病内科收治的70例MCN患者随机分为联合用药组(CM组,n=35)与泼尼松组(PNS组,n=35)。对两组患者均进行常规治疗,在此基础上用小剂量的泼尼松对PNS组患者进行治疗,用吗替麦考酚酯联合小剂量的泼尼松对CM组患者进行治疗,然后比较两组患者的24 h尿蛋白定量、血清肌酐和血浆白蛋白的水平及其病情的总缓解率。结果:治疗后,CM组患者的24 h尿蛋白定量和血清肌酐的水平均低于PNS组患者,其血浆白蛋白的水平高于PNS组患者,P<0.05。治疗后,CM组患者病情的总缓解率高于PNS组患者,P<0.05。结论:对MCN患者进行常规治疗的基础上,用吗替麦考酚酯联合小剂量泼尼松对其进行治疗能显著改善其肾功能,缓解其病情。
Objective:To investigate the clinical effect of minimal change nephropathy(MCN)under the treatment of mycophenol ester combined with minimal dose prednisone.Methods:In recent years,70 MCN patients admitted to the Nephrology Department of Gaozhou People’s Hospital were randomly divided into the combined drug group(CM group,n=35)and prednisone group(PNS group,n=35).To conventional treatment,two groups of patients on the basis of using small doses of prednisone treatment in patients with PNS group,use it for 7 of phenol ester in combination with small dose of prednisone treatment,patients with CM group patients was compared between the two groups of 24 h urine protein quantitatively,the levels of serum creatinine and plasma albumin and total remission rate of illness.Results:After treatment,the urine protein level and serum creatinine level of CM group were lower than those of PNS group at 24 h,and the plasma albumin level was higher than that of PNS group(P<0.05).After treatment,the total remission rate of CM group was higher than that of PNS group(P<0.05).Conclusion:On the basis of conventional treatment of MCN patients,morticopecyl ester combined with low dose prednisone can significantly improve their renal function and alleviate their condition.
作者
陈亮
Chen liang(Department of Nephropathy,Gaozhou People’s Hospital,Gaozhou 525200,China)
关键词
吗替麦考酚酯
小剂量
泼尼松
微小病变性肾病
Mycophenol ester
Small doses
Prednisone
Microdegenerative kidney disease
