摘要
目的探讨胃蛋白酶原Ⅰ(PGⅠ)和胃蛋白酶原Ⅱ(PGⅡ)检测在胃癌筛查中的应用价值,为胃癌筛查提供简单、快捷的筛查方法。方法选取2018年1月~2019年4月间胃癌患者25例,萎缩性胃炎患者40例,胃溃疡患者46例,浅表性胃炎患者50例,健康体检人员50例。分别检测血清PGⅠ与PGⅡ水平,并计算PGⅠ/PGⅡ值。比较各组的阳性检出率。结果胃癌组和萎缩性胃炎组患者的PGⅠ水平、PGⅠ/PGⅡ值均较胃溃疡组、浅表性胃炎组、健康对照组降低,差异有统计学意义(P<0.05)。胃癌组患者的阳性检出率明显高于萎缩性胃炎组、胃溃疡组、浅表性胃炎组、健康对照组,差异有统计学意义(P<0.05)。结论PGⅠ、PGⅡ检测有助于早期发现胃癌,并且简单、无创。对于40岁以上的人群,若PGⅠ<70ng/mL和PGⅠ/PGⅡ<3.0,则建议接受内视镜检查。
Objective To investigate the application value of pepsinogenⅠ(PGⅠ)and pepsinogenⅡ(PGⅡ)in gastric cancer screening,and to provide a simple and fast method for gastric cancer screening.Methods From January 2018 to April 2019,25 patients with gastric cancer,40 patients with atrophic gastritis,46 patients with gastric ulcer,50 patients with superficial gastritis,and 50 patients with healthy physical examination were selected.Serum PGⅠand PGⅡlevels were detected respectively,and PGⅠ/PGⅡvalue was calculated.The positive detection rate of each group was compared.Results The PGⅠlevels,and PGⅠ/PGⅡvalues of patients in the gastric cancer group and atrophic gastritis group were lower than those in the gastric ulcer group,superficial gastritis group and healthy control group,and the difference was statistically significant(P<0.05).The positive detection rate of patients in the gastric cancer group was significantly higher than that in the atrophic gastritis group,gastric ulcer group,superficial gastritis group and healthy control group,and the difference was statistically significant(P<0.05).Conclusion The PGⅠand PGⅡtests are helpful for the early detection of gastric cancer,and are simple and non-invasive.Endoscopy is recommended for people over 40 years old in case of PGⅠ<70ng/mL and PGⅠ/PGⅡ<3.0.
作者
崔碧云
刘月明
黄毓麟
CUI Biyun;LIU Yueming;HUANG Yulin(Department of Laboratory Medicine,People's Hospital of Longchuan,Guangdong,Longchuan 517300,China)
出处
《中国医药科学》
2020年第13期132-134,共3页
China Medicine And Pharmacy
基金
广东省河源市科技计划项目(180620180221798)。
关键词
胃蛋白酶
胃癌筛查
早期胃癌
阳性率
Pepsin
Gastric cancer screening
Early gastric cancer
Positive rate
