摘要
目的:分析≤35岁中国乳腺癌患者内分泌治疗中卵巢功能抑制对患者抑郁、焦虑等心理状态的影响。方法:收集2018—2019年就诊于中国医学科学院肿瘤医院乳腺内科门诊且正在接受辅助内分泌治疗的91例乳腺癌术后患者的人口社会学特征、临床病理资料和治疗方案。采用患者健康问卷抑郁量表(PHQ-9)和广泛性焦虑量表(GAD-7)评估患者的抑郁和焦虑状态。结果:91例患者中,61例正在行含有卵巢功能抑制的内分泌治疗,30例未行卵巢功能抑制治疗。未行卵巢功能抑制的30例患者中,PHQ-9得分≥8分2例,PHQ-9得分<8分28例;GAD-7得分≥10分1例,GAD-7得分<10分29例。行卵巢功能抑制的61例患者中,PHQ-9得分≥8分19例,PHQ-9得分<8分42例;GAD-7得分≥10分8例,GAD-7得分<10分53例。未行卵巢功能抑制组和行卵巢功能抑制组患者的抑郁发生率分别为6.7%和31.1%,差异有统计学意义(P=0.018);焦虑发生率分别为3.3%和13.1%,差异无统计学意义(P=0.174)。多因素分析显示,内分泌治疗和居住状态与患者发生抑郁均有关(均P<0.05)。结论:在≤35岁中国年轻乳腺癌患者的内分泌治疗中,应用卵巢功能抑制药物可能会造成抑郁症状发生率较高,应重视对这一人群心理状态的评估监测。
Objective To explore whether the addition of ovarian function suppression in endocrine therapy of Chinese breast cancer patients under 35 years old will affect the psychological state.Methods This cross-sectional study enrolled 91 Chinese postoperative breast cancer patients aged 35 years or younger.The depression and anxiety state of patients were assessed by Patient Health Questionnaire-9(PHQ-9)and General Anxiety Disorder-7(GAD-7),and their sociodemographic characteristics were collected.Results Among the 91 patients,61 were receiving ovarian function suppression(OFS)treatment,30 were not.Among the 30 patients with out OFS treatment,2 had PHQ-9 score≥8,28 had PHQ-9 score<8,1 had GAD-7 score≥10,and 29 had GAD-7 score<10.Among the 61 patients with OFS,19 had PHQ-9 score≥8,42 had PHQ-9 score<8,8 had GAD-7 score≥10,and 53 had GAD-7 score<10.The incidence of depression was 6.7% and 31.1%in the non-OFS group and OFS group,respectively(P=0.018).The incidence of anxiety in the two groups was 3.3% and 13.1%,respectively(P=0.174).Univariate analysis showed that the incidence of depression was significantly higher in patients with OFS(P=0.018).After taking into account the sociodemographic factors,pathological stage and treatment of the patients,multivariate analysis showed that the administration of OFS was still significantly related to the incidence of depression(OR=9.14,95%CI=1.52~55.16,P=0.016).There was no significant difference in the incidence of anxiety(P=0.174).Conclusions For Chinese young breast cancer patients under 35 years old,the use of OFS in the adjuvant endocrine therapy may lead to a significant increase in the incidence of depression.We should pay attention to the evaluation and monitoring of the psychological state of this population.
作者
兰波
姜时雨
李涛
马飞
Lan Bo;Jiang Shiyu;Li Tao;Ma Fei(Department of Medical Oncology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China;Department of Psychological Medicine,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences,Beijing 100730,China)
出处
《中华肿瘤杂志》
CAS
CSCD
北大核心
2020年第7期586-589,共4页
Chinese Journal of Oncology
关键词
乳腺肿瘤
年轻
卵巢功能抑制
抑郁
焦虑
Breast neoplasms
Young
Ovarian function suppression
Depression
Anxiety
