摘要
目前,医院感染的主要病原菌是肠杆菌科细菌。由于临床上对于抗菌药物的不合理使用,使得耐碳青霉烯类肠杆菌科细菌(carbapenem-resistant Enterobacteriaceae,CRE)的检出率不断增加,而耐碳青霉烯类肺炎克雷伯菌(carbapenem-resistant Klebsiella pneumoniae,CRKP)是临床所分离CRE中最为常见的。本文将从CRKP感染现状、影响因素、耐药机制等方面进行介绍,提高人们对CRKP感染的重视和控制,以期对临床治疗CRKP提供有效的抗菌药物及联合治疗方案。
At present,the main pathogen of nosocomial infections is Enterobacteriaceae.Due to the irrational use of antibacterial drugs in the clinic,the detection rate of carbapenem-resistant Enterobacteriaceae(CRE)is increasing,while carbapenem-resistant Klebsiella pneumoniae(CRKP)is the most common CRE in clinical isolates.This article will introduce the status quo of CRKP infections,influencing factors,drug resistance mechanisms,to improve people’s attention and control of CRKP infection,in order to provide effective antibacterial drugs and clinical combination treatment of CRKP.
作者
王珊珊
吴忠伟
赵建平
Wang Shan-shan;Wu Zhong-wei;Zhao Jian-ping(Inner Mongolia Clinical Medical College,Inner Mongolia Medical University,Hohhot 010050;Department of Clinical Laboratory,Inner Mongolia Autonomous Region People’s Hospital,Hohhot 010010)
出处
《中国抗生素杂志》
CAS
CSCD
2020年第5期428-432,共5页
Chinese Journal of Antibiotics
基金
内蒙古自治区自然科学基金项目(No.2017MS08144)。
关键词
碳青霉烯类
肺炎克雷伯菌
医院感染
耐药机制
治疗
Carbapenem
Klebsiella pneumoniae
Hospital infection
Resistance mechanism
Treatment
