摘要
目的系统评价肾康注射液联合羟苯磺酸钙治疗慢性肾脏病的临床效果与安全性。方法计算机检索PubMed、万方数据库和中国期刊全文数据库,收集关于评价肾康注射液联合羟苯磺酸钙治疗慢性肾脏病疗效及安全性的临床研究,检索时限均从建库至2019年12月25日。采用RevMan5.3软件进行分析。结果共纳入7个随机对照研究,包括653例患者。Meta分析结果显示:与羟苯磺酸钙组相比,肾康注射液联合羟苯磺酸钙能降低Scr[MD=-31.45,95%CI(-50.23,-12.66),P=0.001]、BUN[MD=-3.52,95%CI(-5.24,-1.79),P<0.0001]、UA[MD=-79.72,95%CI(-100.75,-58.69),P<0.00001]、CysC[MD=-1.04,95%CI(-1.34,-0.73),P<0.00001],提高Ccr[MD=9.81,95%CI(7.13,12.50),P<0.00001]、总有效率[OR=4.56,95%CI(2.24,9.30),P<0.0001];而两组患者不良反应发生率比较,差异无统计学意义[OR=0.66,95%CI(0.27,1.63),P=0.37]。结论肾康注射液联合羟苯磺酸钙治疗慢性肾脏病的疗效优于单用羟苯磺酸钙,两组安全性相当。
Objective To evaluate the clinical efficacy and safety of Shenkang injection combined with calcium dobesilate in the treatment of chronic kidney disease. Methods We searched PubMed,Wanfang,and CNKI databases to collect clinical research results on evaluating the efficacy and safety of Shenkang injection combined with calcium dobesilate in the treatment of chronic kidney disease. The search time period was from the establishment of the database to December 25,2019. The RevMan5.3 software was used for meta-analysis.Results A total of 7 randomized controlled trials(RCTs) were included,including 653 patients. The results of the meta-analysis showed that compared with calcium dobesilate group,Scr decreased[MD =-31. 45,95%CI(-50. 23,-12. 66),P = 0. 001],BUN decreased[MD =-3. 52,95%CI(-5. 24,-1. 79),P < 0. 000 01],UA decreased[MD =-79. 72,95%CI(-100. 75,-58. 69),P < 0. 000 01],CysC decreased[MD =-1. 04,95%CI(-1. 34,-0. 73),P < 0. 000 01],Ccr increased[MD = 9. 81,95%CI(7. 13,12. 50),P < 0. 000 01],and total effective rate increased[OR = 4. 56,95%CI(2. 24,9. 30),P < 0. 000 1]in Shenkang injection combined with calcium dobesilate group;and the incidence of adverse reactions between the two groups was not statistically significant[OR = 0. 66,95%CI(0. 27,1. 63),P = 0. 37]. Conclusion The efficacy of Shenkang injection combined with calcium dobesilate in the treatment of chronic kidney disease is better than that of calcium dobesilate alone. The safety of the two groups is equivalent.
作者
尚伟锋
李园园
李维
宋小红
李承旭
董骏武
SHANG Weifeng;LI Yuanyuan;LI Wei;SONG Xiaohong;LI Chengxu;DONG Junwu(Department of Nephrology,Wuhan Fourth Hospital,Puai Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430033,Hubei,China)
出处
《江汉大学学报（自然科学版）》
2020年第4期24-29,共6页
Journal of Jianghan University：Natural Science Edition
基金
湖北省自然科学基金面上项目(2014CFC1047)。
